Histone H4 Antikörper (acLys16)

Produktnummer ABIN2668880

Produktdetails anti-Histone H4 Antikörper

Highlights:

• High quality Histone H4 Primärantikörper for the detection of Histone H4.
• Reliable product with high standard validation data

Target: Histone H4

Bindungsspezifität: acLys16

Reaktivität: Human, Saccharomyces cerevisiae, Drosophila melanogaster

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Histone H4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), Dot Blot (DB), ChIP DNA-Sequencing (ChIP-seq)

Aufreinigung: None

Immunogen: This Histone H4 acetylLys16 antibody was raised against a peptide including acetyllysine 16 of histone H4.

Produktspezifische Information:

What can the Histone H4 Antibody ABIN2668880 be used for?: This polyclonal Histone H4 Antibody detects Histone H4. The Histone H4 Antibody has been validated for various applications and can be used for the detection of Histone H4 and derivatives by Western Blotting, Chromatin Immunoprecipitation, Dot Blot, ChIP DNA-Sequencing.

What validation data is available for this Histone H4 Antibody?: The Primärantikörper is referenced in 15 publications and is characterized by a proven, very high reliability. It has currently 5 product images that show its performance in a variety of applications. The product is currently available in 10 μL, 100 μL quantities. Histone H4 Antibody for the detection of Histone H4 and derivatives.

What is the function of Histone H4?: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails\; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated\; this record represents the centromeric copy. [provided by RefSeq, Jul 2008].

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung:

Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Lagerung: -20 °C

Informationen zur Lagerung: Antibodies in solution can be stored at -20 °C for 2 years.

Haltbarkeit: 6 months

Referenzen für anti-Histone H4 Antikörper (ABIN2668880)

Verrier, Taglini, Barrales, Webb, Urano, Braun, Bayne: "Global regulation of heterochromatin spreading by Leo1." in: Open biology, Vol. 5, Issue 5, (2015) (PubMed).

Sedic, Skibinski, Brown, Gallardo, Mulligan, Martinez, Keller, Glover, Richardson, Cowan, Toland, Ravichandran, Riethman, Naber, Näär, Blasco, Hinds, Kuperwasser: "Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence." in: Nature communications, Vol. 6, pp. 7505, (2015) (PubMed).

Korb, Herre, Zucker-Scharff, Darnell, Allis: "BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice." in: Nature neuroscience, Vol. 18, Issue 10, pp. 1464-73, (2015) (PubMed).

Froyd, Kapoor, Dietrich, Rusche: "The deacetylase Sir2 from the yeast Clavispora lusitaniae lacks the evolutionarily conserved capacity to generate subtelomeric heterochromatin." in: PLoS genetics, Vol. 9, Issue 10, pp. e1003935, (2013) (PubMed).

Wang, Tadeo, Hou, Tu, Thompson, Yates, Jia: "Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries." in: Genes & development, Vol. 27, Issue 17, pp. 1886-902, (2013) (PubMed).

Thijssen, Tobi, Balog, Schouten, Kremer, El Bouazzaoui, Henneman, Putter, Eline Slagboom, Heijmans, van der Maarel: "Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes." in: Epigenetics, Vol. 8, Issue 5, pp. 512-21, (2013) (PubMed).

Badeaux, Yang, Cardenas, Vemulapalli, Chen, Kusewitt, Richie, Li, Bedford: "Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF." in: The Journal of biological chemistry, Vol. 287, Issue 1, pp. 429-37, (2012) (PubMed).

Krogan, Hogan, Long: "APETALA2 negatively regulates multiple floral organ identity genes in Arabidopsis by recruiting the co-repressor TOPLESS and the histone deacetylase HDA19." in: Development (Cambridge, England), Vol. 139, Issue 22, pp. 4180-90, (2012) (PubMed).

Yuan, Rossetto, Mellert, Dang, Srinivasan, Johnson, Hodawadekar, Ding, Speicher, Abshiru, Perry, Wu, Yang, Zheng, Speicher, Thibault, Verreault, Johnson, Berger, Sternglanz, McMahon, Côté, Marmorstein: "MYST protein acetyltransferase activity requires active site lysine autoacetylation." in: The EMBO journal, Vol. 31, Issue 1, pp. 58-70, (2012) (PubMed).

Larsson, Ulfhammer, Magnusson, Bergh, Lunke, El-Osta, Medcalf, Svensson, Karlsson, Jern: "Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression." in: PLoS ONE, Vol. 7, Issue 2, pp. e31573, (2012) (PubMed).

McCullough, Xu, Dent, Bekiranov, Roeder, Grant: "Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 52, pp. 21319-24, (2012) (PubMed).

Liu, McConnell, Dixon, Calvi: "Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex." in: Molecular biology of the cell, Vol. 23, Issue 1, pp. 200-12, (2012) (PubMed).

Sotillo, Laver, Mellert, Schelter, Cleary, McMahon, Thomas-Tikhonenko: "Myc overexpression brings out unexpected antiapoptotic effects of miR-34a." in: Oncogene, Vol. 30, Issue 22, pp. 2587-94, (2011) (PubMed).

Regnard, Straub, Mitterweger, Dahlsveen, Fabian, Becker: "Global analysis of the relationship between JIL-1 kinase and transcription." in: PLoS genetics, Vol. 7, Issue 3, pp. e1001327, (2011) (PubMed).

Kumari, Biacsi, Usdin: "Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4209-15, (2011) (PubMed).

Details zu Histone H4

Target: Histone H4

Abstract: Histone H4 Produkte

Synonyme: hist1h4l antikoerper, H1ft antikoerper, Hist4 antikoerper, Hist4h4 antikoerper, H4 antikoerper, X04652 antikoerper, FO108 antikoerper, H4/n antikoerper, H4F2 antikoerper, H4FN antikoerper, HIST2H4 antikoerper, H4C13 antikoerper, H4C7 antikoerper, F8N16.2 antikoerper, F8N16_2 antikoerper, histone H4 antikoerper, BcDNA:RH52884 antikoerper, CG3379 antikoerper, Dmel\CG3379 antikoerper, H4r antikoerper, His4-88CD antikoerper, His4R antikoerper, histone cluster 1, H4a L homeolog antikoerper, histone cluster 1 H4 family member B antikoerper, histone cluster 2, H4 antikoerper, histone cluster 2 H4 family member a antikoerper, histone H4 antikoerper, Histone H4 replacement antikoerper, Histone H4 antikoerper, hist1h4a.L antikoerper, Hist1h4b antikoerper, Hist2h4 antikoerper, HIST2H4A antikoerper, H4 antikoerper, H4C14 antikoerper, HIS4 antikoerper, HIST2H4 antikoerper, His4r antikoerper, his-38 antikoerper

Molekulargewicht: 8 kDa

Gen-ID: 121504