Reacts with the heavily glycosylated 120 kD lysosmal-associated protein, LAMP-2. LAMP-2 is a widely expressed intracellular antigen. It is also expressed on the surface of activated platelets, PHA-activated lymphocytes and some tumor cell lines, including U937 and KG1a. LAMP-2 has been shown to be a ligand for E-selectin-mediated cell adhesion. LAMP-1 (CD107a) and LAMP-2 are carriers for poly-N-acetyllactosamines, and are able to display sialyl Le[x] termini. Profile of intracellular staining of Jurkat cells fixed and permeabilized with Cytofix/Cytoperm (Cat. No. 554714) and analyzed on a FACScan
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store undiluted at 4°C.
Febbraio, Silverstein: "Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein." in: The Journal of biological chemistry, Vol. 265, Issue 30, pp. 18531-7, (1990) (PubMed).
Chen, Cha, Yuksel, Gracy, August: "Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens." in: The Journal of biological chemistry, Vol. 263, Issue 18, pp. 8754-8, (1988) (PubMed).
Target
LAMP2
(Lysosomal-Associated Membrane Protein 2 (LAMP2))