CD3 Antikörper
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- Target Alle CD3 Antikörper anzeigen
- CD3
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Reaktivität
- Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD3 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB), Cytotoxicity Test (CyTox)
- Marke
- BD Pharmingen™
- Produktmerkmale
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The G4.18 antibody reacts with the T-cell receptor-associated CD3 cell-surface antigen found on thymocytes, peripheral T lymphocytes, and dendritic epidermal T cells. It has been reported that CD3 expression is down-regulated within 24 hours in concanavalin A-stimulated rat T cells, and soluble mAb inhibits the allogeneic mixed-lymphocyte proliferative response and cell-mediated cytotoxicity to allogeneic target cells. In vivo treatment with G4.18 mAb prevents cardiac and skin allograft rejection, resulting in donor-specific tolerance. Pre-incubation of splenocytes with the alternate anti-rat CD3 monoclonal antibody, 1F4 (Cat. No. 556970), blocks staining with mAb G4.18.
BD Pharmingen™ Purified Mouse Anti-Rat CD3 - Purified - Clone G4.18 - Isotype Mouse IgG3, κ - Reactivity Rat - 0.1 mg - Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- PHA-stimulated rat lymph node and spleen cells
- Klon
- G4-18
- Isotyp
- IgG3 kappa
- Top Product
- Discover our top product CD3 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing protein stabilizer and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store undiluted at 4°C.
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Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats." in: Journal of pharmacological and toxicological methods, Vol. 37, Issue 1, pp. 37-46, (1997) (PubMed).
: "Regulation of T-cell activation in the lung: alveolar macrophages induce reversible T-cell anergy in vitro associated with inhibition of interleukin-2 receptor signal transduction." in: Immunology, Vol. 87, Issue 2, pp. 250-8, (1996) (PubMed).
: "Alloreactive natural killer cells in the rat: complex genetics of major histocompatibility complex control." in: European journal of immunology, Vol. 25, Issue 5, pp. 1249-56, (1995) (PubMed).
: "Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion." in: Immunology, Vol. 84, Issue 1, pp. 142-7, (1995) (PubMed).
: "Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody." in: Transplantation, Vol. 55, Issue 3, pp. 459-68, (1993) (PubMed).
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Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats." in: Journal of pharmacological and toxicological methods, Vol. 37, Issue 1, pp. 37-46, (1997) (PubMed).
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- Target
- CD3
- Andere Bezeichnung
- CD3 (CD3 Produkte)
- Synonyme
- CD3 antikoerper, AI504783 antikoerper, CD3epsilon antikoerper, T3e antikoerper, cd3-gamma antikoerper, cd3g antikoerper, cd3g-a antikoerper, cd3g/d antikoerper, cd3gd antikoerper, t3g antikoerper, CD3e molecule antikoerper, CD3d molecule antikoerper, CD3 antigen, epsilon polypeptide antikoerper, CD3g molecule S homeolog antikoerper, CD3E antikoerper, CD3D antikoerper, Cd3e antikoerper, cd3g.S antikoerper
- Pathways
- T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway
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