CD77 Antikörper

Produktnummer ABIN2689395

Produktdetails anti-CD77 Antikörper

Target: CD77

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD77 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Reacts with CD77, a small neutral glycosphingolipid, 1 kDa, also referred to as globotriaosylceramide (Gb3). CD77 is expressed on a subset of germinal center B-lymphocytes and not on peripheral blood lymphocytes, bone marrow or spleen. It has been described as a receptor for Shiga Toxin, produced by Shigella dysenteriae, and Verotoxin 1 (VT1), produced by some strains of E. coli. CD19 has been reported as a ligand for CD77 and these interaction functions in adhesion and signal transduction at a specific stage of B cell development. Studies have shown that cross-linking CD77 induces apoptosis in some B cell lines. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of Ramos cell line analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD77 - Purified - Clone 5B5 - Isotype Mouse IgM, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 5B5

Isotyp: IgM kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-CD77 Antikörper (ABIN2689395)

Lagresle, Bella, Daniel, Krammer, Defrance: "Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 11, pp. 5746-56, (1995) (PubMed).

Mangeney, Rousselet, Taga, Tursz, Wiels: "The fate of human CD77+ germinal center B lymphocytes after rescue from apoptosis." in: Molecular immunology, Vol. 32, Issue 5, pp. 333-9, (1995) (PubMed).

Fyfe, Cebra-Thomas, Mustain, Davie, Alley, Nahm: "Subpopulations of B lymphocytes in germinal centers." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 139, Issue 7, pp. 2187-94, (1987) (PubMed).

Details zu CD77

Target: CD77

Abstract: CD77 Produkte