LY6D Antikörper

Produktnummer ABIN2689823

Produktdetails anti-LY6D Antikörper

Target: LY6D (Lymphocyte Antigen 6 Complex, Locus D (LY6D))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser LY6D Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Cytotoxicity Test (CyTox)

Marke: BD Pharmingen™

Produktmerkmale: The 49-H4 antibody reacts with the ThB antigen (Ly-6D), which is a 15- kDa GPI-anchored protein of the Ly-6 multigene family. ThB has been detected on cortical thymocytes, small sIg- Thy-1- and sIg+ lymphoid cells in the bone marrow, thymic medullary epithelial cells, all epidermal layers (except the stratum corneum), and on peripheral B lymphocytes, but not on peripheral T lymphocytes. It has been noted that there is strain-to-strain variation in the expression of the ThB antigen on splenic B cells, those of strains with the Ly-6.2 haplotype (e.g., AKR, C57BL, DBA/2, SJL, SWR) stain more intensely with anti- ThB reagents than those of Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, NZB), and B cells of hybrids of Ly-6.1 and Ly-6.2 strains stain with intermediate intensity. The proportions of the ThB+ B cells and thymocytes do not differ significantly among strains.

BD Pharmingen™ Purified Rat Anti-Mouse Ly-6D - Purified - Clone 49-H4 - Isotype Rat IgG2c, κ - Reactivity Ms - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: BALB/c mouse plasmacytoma MOPC-104E

Klon: 49

Isotyp: IgG2c kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-LY6D Antikörper (ABIN2689823)

Gumley, McKenzie, Sandrin: "Polymorphism at the mouse Thb locus." in: Immunogenetics, Vol. 39, Issue 6, pp. 390-4, (1994) (PubMed).

Boyd, Tucek, Godfrey, Izon, Wilson, Davidson, Bean, Ladyman, Ritter, Hugo: "The thymic microenvironment." in: Immunology today, Vol. 14, Issue 9, pp. 445-59, (1993) (PubMed).

Gumley, McKenzie, Kozak, Sandrin: "Isolation and characterization of cDNA clones for the mouse thymocyte B cell antigen (ThB)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 8, pp. 2615-8, (1992) (PubMed).

Godfrey, Izon, Tucek, Wilson, Boyd: "The phenotypic heterogeneity of mouse thymic stromal cells." in: Immunology, Vol. 70, Issue 1, pp. 66-74, (1990) (PubMed).

Matossian-Rogers, Rogers, Ledbetter, Herzenberg: "Molecular weight determination of two genetically linked cell surface murine antigens: ThB and Ly-6." in: Immunogenetics, Vol. 15, Issue 6, pp. 591-9, (1982) (PubMed).

Eckhardt, Herzenberg: "Monoclonal antibodies to ThB detect close linkage of Ly-6 and a gene regulating ThB expression." in: Immunogenetics, Vol. 11, Issue 3, pp. 275-91, (1981) (PubMed).

Details zu LY6D

Target: LY6D (Lymphocyte Antigen 6 Complex, Locus D (LY6D))

Andere Bezeichnung: Ly-6D (LY6D Produkte)

Synonyme: E48 antikoerper, Ly-6D antikoerper, Ly-61 antikoerper, Ly61 antikoerper, Thb antikoerper, lymphocyte antigen 6 family member D antikoerper, lymphocyte antigen 6 complex, locus D antikoerper, LY6D antikoerper, Ly6d antikoerper

Hintergrund: Synonyms: ThB