TDP2 Antikörper
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- Target Alle TDP2 Antikörper anzeigen
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TDP2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS)
- Verwendungszweck
- Anti-EAPII Unconjugated Antibody
- Produktmerkmale
- EAPII (also called TTRAP, TDP2) originally was identified as an interacting partner of oncogene ETS1, a founding member of ets transcription factor, and the cytoplasmic domain of CD40, a member of the tumor necrosis factor (TNF) receptor family. EAPII significantly represses ETS1 transcriptional activity and the synergistic transactivation by ETS1 and AP-1 or by ETS1 and NFκB. EAPII/TTRAP also inhibits the transcriptional activation of NFB induced by CD40 or phorbol 12-myristate 13-acetate (PMA). Recently this protein was also proven to be the first 5'- tyrosyl-DNA phosphodiesterase. EAPII has been demonstrated to have promiscuous protein associations, broad responsiveness to various extracellular signals, and pleiotropic functions in the development of human diseases including cancer and neurodegenerative disease. Emerging data suggest that EAPII is a multi-functional protein: it repairs enzyme (topoisomerase)-mediated DNA damage by removing phosphotyrosine from DNA adducts, involves in multiple signal transduction pathways such as TNF-TNFR, TGFβ and MAPK, and responsive to immune defense including inflammatory response, viral infection and DNA toxins (chemo or radiation therapy). EAPII predominantly localizes to the nucleus, but based on pathological conditions it also localizes in both cytoplasm and nucleus.
- Aufreinigung
- Purified
- Reinheit
- >95 %
- Güteklasse
- GMP Grade
- Immunogen
- Recombinant full length protein
- Klon
- 42c
- Isotyp
- IgG2b, kappa
- Top Product
- Discover our top product TDP2 Primärantikörper
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anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 246-272), (C-Term) antibody
TDP2 Reaktivität: Human WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB20005 unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 1-362) antibodyTDP2 Reaktivität: Human WB, IF Wirt: Maus Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 1-362) antibodyTDP2 Reaktivität: Human WB, ELISA, IHC (p) Wirt: Maus Monoclonal 3D11 unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (Middle Region) antibodyTDP2 Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 253-281), (C-Term) antibodyTDP2 Reaktivität: Human WB, IF, FACS, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibodyTDP2 Reaktivität: Human IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 154-203) antibodyTDP2 Reaktivität: Human, Maus, Ratte, Kaninchen, Meerschweinchen, Fledermaus, Affe, Zebrafisch (Danio rerio) WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibodyTDP2 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 29-305) antibodyTDP2 Reaktivität: Human WB, IHC, IF, IHC (p), ICC Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.5 mg/mL
- Buffer
- PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
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- Target
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
- Andere Bezeichnung
- EAPII (TDP2 Produkte)
- NCBI Accession
- NM_016614
- UniProt
- O95551
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