p53 Antikörper
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- Target Alle p53 (TP53) Antikörper anzeigen
- p53 (TP53) (Tumor Protein P53 (TP53))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser p53 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of p53 protein. (region surrounding Met1)
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- Reinheit
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product TP53 Primärantikörper
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anti-Tumor Protein P53 (TP53) (N-Term) antibody
TP53 Reaktivität: Human WB, IF, IHC (p), IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) antibodyKO Validated TP53 Reaktivität: Human WB, IF, IHC (p), IP, ICC, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (pSer392) antibodyTP53 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 1-100) antibodyTP53 Reaktivität: Human WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 301-393) antibodyTP53 Reaktivität: Human, Maus, Ratte, Ziege WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 293-322) antibodyTP53 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB7777 unconjugated
anti-Tumor Protein P53 (TP53) (pSer33) antibodyTP53 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 94-201) antibodyTP53 Reaktivität: Human WB, ELISA, IF, IHC (p), IP Wirt: Maus Monoclonal 2C3 unconjugated
anti-Tumor Protein P53 (TP53) (AA 94-201) antibodyTP53 Reaktivität: Human WB, ELISA, IHC (p), PLA, RNAi Wirt: Maus Monoclonal 2C11 unconjugated
anti-Tumor Protein P53 (TP53) (acLys319) antibodyTP53 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- DO NOT FREEZE!
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C.
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- Target
- p53 (TP53) (Tumor Protein P53 (TP53))
- Andere Bezeichnung
- p53 (TP53) (TP53 Produkte)
- Hintergrund
- P53, a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active (DNA-binding) conformations and is differentially activated through posttranslational modifications including phosphorylation and acetylation.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
- Molekulargewicht
- approx. 53,43 kDa
- Gen-ID
- 7157
- NCBI Accession
- NP_000537
- UniProt
- P04637
- Pathways
- p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt
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