beta Arrestin 1 Antikörper
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- Target Alle beta Arrestin 1 (ARRB1) Antikörper anzeigen
- beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser beta Arrestin 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of Arrestin 1 protein. (region surrounding Glu406)
- Kreuzreaktivität (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- Reinheit
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product ARRB1 Primärantikörper
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- Applikationshinweise
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ELISA: 1: 1000approx. 1: 5000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- DO NOT FREEZE!
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C.
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- Target
- beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
- Andere Bezeichnung
- Arrestin beta-1 / ARRB1 (ARRB1 Produkte)
- Synonyme
- arrb1 antikoerper, MGC83787 antikoerper, arb1 antikoerper, arr1 antikoerper, barr1 antikoerper, betaarr1 antikoerper, 1200006I17Rik antikoerper, AW208571 antikoerper, G430100A01Rik antikoerper, ARB1 antikoerper, ARR1 antikoerper, BARRES antikoerper, arrestin beta 1 antikoerper, arrestin, beta 1 antikoerper, arrestin beta 1 L homeolog antikoerper, beta-arrestin 1 antikoerper, putative beta-arrestin 1 antikoerper, ARRB1 antikoerper, arrb1 antikoerper, arrb1.L antikoerper, CpipJ_CPIJ016988 antikoerper, CpipJ_CPIJ017114 antikoerper, Smp_122900 antikoerper, Smp_126080 antikoerper, Smp_176980 antikoerper, Smp_152290 antikoerper, Arrb1 antikoerper
- Hintergrund
- Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.Synonyms: ARR1, Beta-arrestin-1
- Molekulargewicht
- approx. 50 kDa
- Gen-ID
- 408
- NCBI Accession
- NP_004032
- UniProt
- P49407
- Pathways
- Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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