FOXD3
Reaktivität: Human
Wirt: Kaninchen
Polyclonal
FITC
Applikationshinweise
ELISA: 1: 5000approx. 1: 10000. Western blot: 1: 500approx. 1: 1000. Immunohistochemistry on paraffin sections: 1: 50approx. 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Embryonic stem cells require the forkhead transcriptional regulator FoxD3 for survival. Following gastrulation, FoxD3 generally gets downregulated, except in the neural crest. A variety of growth factors induce FoxD3 expression, including FGF8 and SNAIL, maintaining the effected cells in an undifferentiated state. Thus defects in FoxD3 induction may cause premature differentiation and/or migration-asociated birth defects.Synonyms: Forkhead box protein D3, HNF3/FH transcription factor genesis