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p53 Antikörper

Name: p53 Antikörper
SKU: ABIN2734044
Price: 658.43 EUR
Availability: InStock

TP53 Reaktivität: Human, Maus, Affe WB, IHC, IF, FACS Wirt: Maus Monoclonal 5E2 unconjugated

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TP53 (Right lane) cDNA for 48 hrs and lysed. (p53 Antikörper)

Anti-TP53 mouse monoclonal antibody (ABIN2454551) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TP53 (RC200003). (p53 Antikörper)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-TP53 mouse monoclonal antibody. (p53 Antikörper)

IHC

3 Abbildungen

(2 Referenzen)

Produktnummer ABIN2734044

Datenblatt (PDF)

Target Alle p53 (TP53) Antikörper anzeigen

p53 (TP53) (Tumor Protein P53 (TP53))
Reaktivität
835

255

211

107

50

34

33

19

10

9

7

6

6

3

3

3

3

2

2

2

2

1

1

1
Human, Maus, Affe
Wirt
623

229

6

2

1
Maus
Passende Sekundärantikörper
Klonalität
559

301

1
Monoklonal
Konjugat
485

38

32

19

19

13

13

13

13

13

13

13

13

13

12

12

11

11

11

11

11

11

11

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
Dieser p53 Antikörper ist unkonjugiert
Applikation
668

298

250

202

200

149

128

124

119

68

59

35

18

16

13

12

9

9

8

6

4

3

3

3

3

2

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Produktmerkmale

Homo sapiens tumor protein p53 (TP53), transcript variant 1

Aufreinigung

Purified from mouse ascites fluids by affinity chromatography

Immunogen

Full length human recombinant protein of human TP53 (NP_000537) produced in HEK293T cell.

Klon

5E2

Isotyp

IgG1

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anti-Tumor Protein P53 (TP53) (pSer392) antibody
TP53 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 1-100) antibody
TP53 Reaktivität: Human WB, IHC, IP Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 301-393) antibody
TP53 Reaktivität: Human, Maus, Ratte, Ziege WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 293-322) antibody
TP53 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB7777 unconjugated

anti-Tumor Protein P53 (TP53) (pSer33) antibody
TP53 Reaktivität: Human, Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 94-201) antibody
TP53 Reaktivität: Human WB, ELISA, IF, IHC (p), IP Wirt: Maus Monoclonal 2C3 unconjugated

anti-Tumor Protein P53 (TP53) (AA 94-201) antibody
TP53 Reaktivität: Human WB, ELISA, IHC (p), PLA, RNAi Wirt: Maus Monoclonal 2C11 unconjugated

anti-Tumor Protein P53 (TP53) (acLys319) antibody
TP53 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100,

Kommentare

The concentration of the product may vary between diferrent lots.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

0.5-1.0 mg/mL

Buffer

PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

-20 °C
Zhao, Zhang, Sun, Zhan, Zhao: "Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest." in: Oncology research, Vol. 23, Issue 5, pp. 237-48, (2016) (PubMed).

Dang, Chen, Madura: "Catalytically Active Proteasomes Function Predominantly in the Cytosol." in: The Journal of biological chemistry, Vol. 291, Issue 36, pp. 18765-77, (2016) (PubMed).
Target

p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung

TP53 (TP53 Produkte)

Hintergrund

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Molekulargewicht

43.5 kDa

Gen-ID

7157

NCBI Accession

NM_000546

HGNC

7157

Pathways

p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt