PDE4D Antikörper

Produktnummer ABIN2747152

Produktdetails anti-PDE4D Antikörper

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE4D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide selective for all PDE4D variants.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.57 μg/μL

Referenzen für anti-PDE4D Antikörper (ABIN2747152)

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Guo, Lin, Zhao, Zhang, Wei, Wang, Wang: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." in: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).

Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." in: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

Dong, Guo, Ye, Hare: "Presynaptic inhibition by α2 receptor/adenylate cyclase/PDE4 complex at retinal rod bipolar synapse." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 28, pp. 9432-40, (2014) (PubMed).

Wang, Zhang, Liu, Zhao, Zhang, Yuan, An, Li, Wang, Qin, Wilson, ODonnell, Zhang, Li: "RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects." in: British journal of pharmacology, Vol. 168, Issue 4, pp. 1001-14, (2013) (PubMed).

Michalski, Kanaji, Liu, Nogel, Wang, Basma, Nakanishi, Sato, Gunji, Fahrid, Nelson, Muller, Holz, Magnussen, Rabe, Toews, Rennard: "Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4." in: American journal of respiratory cell and molecular biology, Vol. 47, Issue 6, pp. 729-37, (2013) (PubMed).

Al-Tawashi, Jung, Liu, Su, Qin: "Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 14644-58, (2012) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Genders, Bradley, Rattigan, Richards: "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 301, Issue 2, pp. E342-50, (2011) (PubMed).

Yougbare, Morin, Senouvo, Sirois, Albadine, Lugnier, Rousseau: "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 4, pp. L441-50, (2011) (PubMed).

Gregg, Steppan, Gonzalez, Champion, Phan, Nyhan, Shoukas, Hare, Barouch, Berkowitz: "β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation." in: Anesthesia and analgesia, Vol. 111, Issue 4, pp. 870-7, (2010) (PubMed).

Zhang, Huang, Masood, Stolinski, Li, Zhang, Dlaboga, Jin, Conti, ODonnell: "Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 33, Issue 7, pp. 1611-23, (2008) (PubMed).

Nomura-Furuwatari, Wakitani, Hashimoto, Imai, Ohta, Nakagawa, Nakao, Takayama, Manaka, Takaoka: "Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells." in: Journal of bone and mineral metabolism, Vol. 26, Issue 2, pp. 152-8, (2008) (PubMed).

Fujita, Imaizumi, DSa, Zoghbi, Crescenzo, Hong, Musachio, Gee, Seidel, Green, Pike, Duman, Innis: "In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration." in: Synapse (New York, N.Y.), Vol. 61, Issue 2, pp. 78-86, (2007) (PubMed).

Creighton, Zhu, Alexeyev, Stevens: "Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation." in: Journal of cell science, Vol. 121, Issue Pt 1, pp. 110-9, (2007) (PubMed).

Baxendale, Fraser: "Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation." in: Molecular reproduction and development, Vol. 71, Issue 4, pp. 495-508, (2006) (PubMed).

Dlaboga, Hajjhussein, ODonnell: "Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram." in: Brain research, Vol. 1096, Issue 1, pp. 104-12, (2006) (PubMed).

Terrin, Di Benedetto, Pertegato, Cheung, Baillie, Lynch, Elvassore, Prinz, Herberg, Houslay, Zaccolo: "PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases." in: The Journal of cell biology, Vol. 175, Issue 3, pp. 441-51, (2006) (PubMed).

Wang, Deng, Bugaj-Gaweda, Kwan, Gunwaldsen, Leonard, Xin, Hu, Unterbeck, De Vivo: "Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7." in: Cellular signalling, Vol. 15, Issue 9, pp. 883-91, (2004) (PubMed).

Details zu PDE4D

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Andere Bezeichnung: PDE4D (PDE4D Produkte)

Synonyme: ACRDYS2 antikoerper, DPDE3 antikoerper, HSPDE4D antikoerper, PDE43 antikoerper, PDE4DN2 antikoerper, STRK1 antikoerper, CMYA2 antikoerper, MMGL antikoerper, 9630011N22Rik antikoerper, Dpde3 antikoerper, 4732458A06Rik antikoerper, 9430063L05Rik antikoerper, C87016 antikoerper, D130016K21Rik antikoerper, D3Bwg1078e antikoerper, Usmg4 antikoerper, mKIAA0454 antikoerper, si:dkey-190g11.2 antikoerper, phosphodiesterase 4D antikoerper, phosphodiesterase 4D interacting protein antikoerper, phosphodiesterase 4D, cAMP specific antikoerper, phosphodiesterase 4D, cAMP-specific antikoerper, phosphodiesterase 4D interacting protein (myomegalin) antikoerper, PDE4D antikoerper, PDE4DIP antikoerper, pde4d antikoerper, Pde4dip antikoerper, Pde4d antikoerper

UniProt: Q07343

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling