CD13 Antikörper

Produktnummer ABIN2749014

Produktdetails anti-CD13 Antikörper

Target: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD13 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Functional Studies (Func)

Spezifität: The antibody WM15 recognises an extracellular epitope of human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.

Kreuzreaktivität (Details): Human, Non-Human Primates

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Endotoxin-Niveau: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogen: Human AML cells

Klon: WM15

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Functional application: The antibody WM15 inhibits infection of cells by human coronavirus and inhibits aminopeptidase N activity of the CD13 Molecule immunoprecipitates.
Flow cytometry: Recommended dilution: 1-4 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-CD13 Antikörper (ABIN2749014)

McCormack, Muji?, Osdal, Bruserud, Gjertsen: "Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia." in: Blood, Vol. 121, Issue 7, pp. e34-42, (2013) (PubMed).

Favaloro, Browning, Facey: "CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated." in: Experimental hematology, Vol. 21, Issue 13, pp. 1695-701, (1993) (PubMed).

Bradstock, Favaloro, Kabral, Kerr, Hughes, Berndt, Musgrove: "Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells." in: Pathology, Vol. 17, Issue 3, pp. 392-9, (1986) (PubMed).

Bradstock, Favaloro, Kabral, Kerr, Hughes, Musgrove: "Myeloid progenitor surface antigen identified by monoclonal antibody." in: British journal of haematology, Vol. 61, Issue 1, pp. 11-20, (1985) (PubMed).

Details zu CD13

Target: CD13 (ANPEP) (Alanyl (Membrane) Aminopeptidase (ANPEP))

Andere Bezeichnung: CD13 (ANPEP Produkte)

Synonyme: APN antikoerper, CD13 antikoerper, GP150 antikoerper, LAP1 antikoerper, P150 antikoerper, PEPN antikoerper, A2AP antikoerper, AAP antikoerper, ALPHA-2-PI antikoerper, API antikoerper, PLI antikoerper, AAT1 antikoerper, ALT1 antikoerper, GPT1 antikoerper, Gpt1 antikoerper, Apn antikoerper, pepN antikoerper, SC8E4A.13 antikoerper, 1300007J06Rik antikoerper, 2310022B03Rik antikoerper, ALT antikoerper, Gpt-1 antikoerper, AP-M antikoerper, AP-N antikoerper, Cd13 antikoerper, Apm antikoerper, KZP antikoerper, Lap1 antikoerper, rAPN antikoerper, APDE antikoerper, p150 antikoerper, anpep antikoerper, fb64c05 antikoerper, wu:fb64c05 antikoerper, zgc:136771 antikoerper, alanyl aminopeptidase, membrane antikoerper, serpin family F member 2 antikoerper, glutamic--pyruvic transaminase antikoerper, aminopeptidase N antikoerper, aminopeptidase antikoerper, aminopeptidase n antikoerper, glutamic pyruvic transaminase, soluble antikoerper, alanyl (membrane) aminopeptidase antikoerper, membrane alanyl aminopeptidase antikoerper, alanyl (membrane) aminopeptidase b antikoerper, alanyl aminopeptidase, membrane L homeolog antikoerper, ANPEP antikoerper, SERPINF2 antikoerper, GPT antikoerper, Gpt antikoerper, Apn2 antikoerper, Apn1 antikoerper, SCO2643 antikoerper, pepN antikoerper, Shewana3_0897 antikoerper, Alvin_1024 antikoerper, Ndas_3413 antikoerper, Saut_1544 antikoerper, Fbal_1877 antikoerper, ML5_3424 antikoerper, Despr_1988 antikoerper, Mesop_5365 antikoerper, Anpep antikoerper, LOC101744250 antikoerper, anpepb antikoerper, anpep.L antikoerper

Hintergrund: Alanyl aminopeptidase, membrane,CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.,Aminopeptidase N, APN, PEPN, ANPEP, gp150, LAP1

Gen-ID: 290

UniProt: P15144

Pathways: Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones