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Integrin beta 2 Antikörper

ITGB2 Reaktivität: Human FACS, WB, IP, Func, IHC (fro), IHC (p) Wirt: Maus Monoclonal MEM-48 unconjugated
Produktnummer ABIN2749019
  • Target Alle Integrin beta 2 (ITGB2) Antikörper anzeigen
    Integrin beta 2 (ITGB2)
    Reaktivität
    • 197
    • 58
    • 44
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 101
    • 96
    • 37
    • 2
    • 1
    Maus
    Klonalität
    • 138
    • 94
    • 2
    Monoklonal
    Konjugat
    • 98
    • 26
    • 22
    • 19
    • 11
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Integrin beta 2 Antikörper ist unkonjugiert
    Applikation
    • 131
    • 88
    • 54
    • 52
    • 41
    • 32
    • 28
    • 26
    • 26
    • 25
    • 21
    • 13
    • 12
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    The antibody MEM-48 recognizes an extracellular epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit, beta2 integrin). CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes.
    Keine Kreuzreaktivität
    Hund
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
    Reinheit
    > 95 % (by SDS-PAGE)
    Endotoxin-Niveau
    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    Immunogen
    Leukocytes of a patient suffering from a LGL-type leukemia.
    Klon
    MEM-48
    Isotyp
    IgG1
    Top Product
    Discover our top product ITGB2 Primärantikörper
  • Applikationshinweise
    Functional application: The antibody MEM-48 induces high-affinity conformation of LFA-1 complex.
    Western blotting: Recommended dilution: 2 μg/mL, positive control: Kg-1a human leukemia cell lysate, non-reducing conditions.
    Flow cytometry: Recommended dilution: 2 μg/mL.
    Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL, positive tissue: spleen, microglia.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Kuttruff, Koch, Kelp, Pawelec, Rammensee, Steinle: "NKp80 defines and stimulates a reactive subset of CD8 T cells." in: Blood, Vol. 113, Issue 2, pp. 358-69, (2009) (PubMed).

    Garnotel, Rittié, Poitevin, Monboisse, Nguyen, Potron, Maquart, Randoux, Gillery: "Human blood monocytes interact with type I collagen through alpha x beta 2 integrin (CD11c-CD18, gp150-95)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 11, pp. 5928-34, (2000) (PubMed).

    Stefanová, Horejsí: "Association of the CD59 and CD55 cell surface glycoproteins with other membrane molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 5, pp. 1587-92, (1991) (PubMed).

    Bazil, Stefanová, Hilgert, Kristofová, Van?k, Horejsí: "Monoclonal antibodies against human leucocyte antigens. IV. Antibodies against subunits of the LFA-1 (CD11a/CD18) leucocyte-adhesion glycoprotein." in: Folia biologica, Vol. 36, Issue 1, pp. 41-50, (1990) (PubMed).

    Larson, Springer: "Structure and function of leukocyte integrins." in: Immunological reviews, Vol. 114, pp. 181-217, (1990) (PubMed).

  • Target
    Integrin beta 2 (ITGB2)
    Andere Bezeichnung
    CD18 (ITGB2 Produkte)
    Synonyme
    CD18 antikoerper, LAD antikoerper, LCAMB antikoerper, LFA-1 antikoerper, MAC-1 antikoerper, MF17 antikoerper, MFI7 antikoerper, 2E6 antikoerper, AI528527 antikoerper, Cd18 antikoerper, Lfa1 antikoerper, ITGB2 antikoerper, itgb2 antikoerper, itgb2-a antikoerper, itgb2-b antikoerper, integrin subunit beta 2 antikoerper, integrin beta 2 antikoerper, integrin subunit beta 2 S homeolog antikoerper, ITGB2 antikoerper, Itgb2 antikoerper, itgb2.S antikoerper
    Hintergrund
    Integrin subunit beta 2,CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 Molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.,Integrin beta2, Complement receptor C3 subunit beta, ITGB2
    Gen-ID
    3689
    UniProt
    P05107
    Pathways
    NF-kappaB Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
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