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Integrin Alpha2b Antikörper

Name: Integrin Alpha2b Antikörper
Brand: antibodies-online
SKU: ABIN2749066
Price: 239.09 EUR
Availability: InStock

CD41 Reaktivität: Maus FACS, ELISA, IHC (fro), IP, IHC (p) Wirt: Ratte Monoclonal MWReg30 unconjugated

Flow cytometry surface staining pattern of murine blood suspension stained using anti-mouse CD41 (MWReg30) purified antibody (concentration in sample 0,6 μg/mL, GAM APC). (Integrin Alpha2b Antikörper)

FACS

Separation of murine CD41 positive thrombocytes (red-filled) from CD41 negative cells (black-dashed) in flow cytometry analysis (surface staining) of murine blood stained using anti-mouse CD41 (MWReg30) purified antibody (concentration in sample 0,6 μg/mL, GAM APC). (Integrin Alpha2b Antikörper)

FACS

2 Abbildungen

(3 Referenzen)

Produktnummer ABIN2749066

Datenblatt (PDF)

Target Alle Integrin Alpha2b (CD41) Antikörper anzeigen

Integrin Alpha2b (CD41)
Reaktivität
123

34

21

5

5

4

3

2

2

2

1

1

1

1

1
Maus
Wirt
79

46

25
Ratte
Passende Sekundärantikörper
Klonalität
100

44

1
Monoklonal
Konjugat
57

16

13

11

5

4

4

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser Integrin Alpha2b Antikörper ist unkonjugiert
Applikation
102

44

26

26

20

19

13

13

10

8

8

5

3

2

1

1

1

1

1

1

1

1

1
Flow Cytometry (FACS), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität

The rat monoclonal antibody MWReg30 recognizes an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain, 120 kDa) and GPIIb beta (light chain, 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.

Kreuzreaktivität (Details)

Mouse

Aufreinigung

Purified by protein-G affinity chromatography.

Reinheit

> 95 % (by SDS-PAGE)

Immunogen

Murine platelets

Klon

MWReg30

Isotyp

IgG1 kappa

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CD41 Reaktivität: Human, Ratte FACS, WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) Wirt: Kaninchen Polyclonal unconjugated

anti-Integrin Alpha2b (CD41) antibody
CD41 Reaktivität: Maus FACS, ELISA, IHC (fro), IP, IHC (p), Func Wirt: Ratte Monoclonal MWReg30 unconjugated

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CD41 Reaktivität: Human, Non-Human Primate FACS, IHC (fro) Wirt: Maus Monoclonal HIP2 unconjugated

anti-Integrin Alpha2b (CD41) antibody (Biotin)
CD41 Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-06 Biotin

anti-Integrin Alpha2b (CD41) antibody (FITC)
CD41 Reaktivität: Human FACS Wirt: Maus Monoclonal MEM-06 FITC

anti-Integrin Alpha2b (CD41) (AA 677-711), (C-Term) antibody
CD41 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

anti-Integrin Alpha2b (CD41) antibody
CD41 Reaktivität: Human, Non-Human Primate FACS, IHC (fro) Wirt: Maus Monoclonal HIP8 unconjugated

anti-Integrin Alpha2b (CD41) (AA 639-887) antibody
CD41 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Integrin Alpha2b (CD41) antibody (PE)
CD41 Reaktivität: Maus FACS Wirt: Ratte Monoclonal MWReg30 PE

Applikationshinweise

Flow cytometry: Recommended dilution: 1-4 μg/mL.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1 mg/mL

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C

Informationen zur Lagerung

Store at 2-8°C. Do not freeze.
Ramsey, Zhang, Brown, Steensma, Lin, Wu: "Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3)." in: Haematologica, Vol. 99, Issue 2, pp. 282-91, (2014) (PubMed).

Boisset, Clapes, Van Der Linden, Dzierzak, Robin: "Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta." in: Biology open, Vol. 2, Issue 5, pp. 525-32, (2013) (PubMed).

Sullivan, Wang, Tawfik, Luyendyk: "Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 115, Issue 1, pp. 286-94, (2010) (PubMed).
Target

Integrin Alpha2b (CD41)

Andere Bezeichnung

CD41 (CD41 Produkte)

Synonyme

AI172977 antikoerper, CD41 antikoerper, CD41B antikoerper, GpIIb antikoerper, alphaIIb antikoerper, BDPLT16 antikoerper, BDPLT2 antikoerper, GP2B antikoerper, GPIIb antikoerper, GT antikoerper, GTA antikoerper, HPA3 antikoerper, integrin alpha 2b antikoerper, integrin subunit alpha 2b antikoerper, Itga2b antikoerper, ITGA2B antikoerper

Hintergrund

Integrin subunit alpha 2b,CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.,Platelet GPIIb, Integrin alpha-IIb, GPalpha IIb, GPIIb

Gen-ID

16399

UniProt

Q9QUM0

Pathways

Integrin Complex