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CD8B Antikörper (FITC)

CD8B Reaktivität: Ratte FACS Wirt: Maus Monoclonal 341 FITC
Produktnummer ABIN2749076
  • Target Alle CD8B Antikörper anzeigen
    CD8B (CD8b Molecule (CD8B))
    Reaktivität
    • 76
    • 31
    • 21
    • 17
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 76
    • 45
    • 23
    Maus
    Klonalität
    • 78
    • 65
    • 1
    Monoklonal
    Konjugat
    • 61
    • 18
    • 16
    • 13
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD8B Antikörper ist konjugiert mit FITC
    Applikation
    • 79
    • 77
    • 45
    • 28
    • 20
    • 17
    • 13
    • 13
    • 10
    • 7
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody 341 (also known as 34.1) recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.
    Kreuzreaktivität (Details)
    Rat
    Aufreinigung
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    CD8 positive Wistar rat splenic T cell hybridomas
    Klon
    341
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CD8B Primärantikörper
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    Kommentare

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Mabarrack, Turner, Mayrhofer: "Recent thymic origin, differentiation, and turnover of regulatory T cells." in: Journal of leukocyte biology, Vol. 84, Issue 5, pp. 1287-97, (2008) (PubMed).

    Nohara, Kulka, Déry, Wills, Hirji, Gilchrist, Befus: "Regulation of CD8 expression in mast cells by exogenous or endogenous nitric oxide." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 10, pp. 5935-9, (2001) (PubMed).

    Ellerman, Like: "Islet cell membrane antigens activate diabetogenic CD4+ T-cells in the BB/Wor rat." in: Diabetes, Vol. 48, Issue 5, pp. 975-82, (1999) (PubMed).

    Lin, Hirji, Nohara, Stenton, Gilchrist, Befus: "Mast cells express novel CD8 molecules that selectively modulate mediator secretion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 6265-72, (1998) (PubMed).

    Hirji, Lin, Bissonnette, Belosevic, Befus: "Mechanisms of macrophage stimulation through CD8: macrophage CD8alpha and CD8beta induce nitric oxide production and associated killing of the parasite Leishmania major." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 6004-11, (1998) (PubMed).

    Kraus, Lambracht, Wonigeit, Hünig: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." in: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, (1997) (PubMed).

    Hirji, Lin, Befus: "A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 4, pp. 1833-40, (1997) (PubMed).

    Torres-Nagel, Kraus, Brown, Tiefenthaler, Mitnacht, Williams, Hünig: "Differential thymus dependence of rat CD8 isoform expression." in: European journal of immunology, Vol. 22, Issue 11, pp. 2841-8, (1992) (PubMed).

  • Target
    CD8B (CD8b Molecule (CD8B))
    Andere Bezeichnung
    CD8b (CD8B Produkte)
    Synonyme
    Cd8b antikoerper, Ly-3 antikoerper, Ly-C antikoerper, Lyt-3 antikoerper, CD8B1 antikoerper, LEU2 antikoerper, LY3 antikoerper, LYT3 antikoerper, P37 antikoerper, Cd8b1 antikoerper, CD8b molecule antikoerper, CD8 antigen, beta chain 1 antikoerper, Cd8b antikoerper, CD8B antikoerper, Cd8b1 antikoerper
    Hintergrund
    CD8b molecule,The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,Ly-3, Ly-C, Lyt-3
    Gen-ID
    926
    UniProt
    P10966
    Pathways
    T-Zell Rezeptor Signalweg
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