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Interferon gamma Antikörper

IFNG Reaktivität: Human, Non-Human Primate WB, ELISA, FACS, IP, ICC, IHC (p), RIA Wirt: Maus Monoclonal 4S-B3 unconjugated
Produktnummer ABIN2749087
  • Target Alle Interferon gamma (IFNG) Antikörper anzeigen
    Interferon gamma (IFNG)
    Reaktivität
    • 225
    • 92
    • 57
    • 28
    • 24
    • 21
    • 18
    • 17
    • 17
    • 16
    • 16
    • 12
    • 11
    • 11
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Non-Human Primate
    Wirt
    • 231
    • 174
    • 47
    • 14
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    Maus
    Klonalität
    • 282
    • 199
    • 1
    Monoklonal
    Konjugat
    • 216
    • 90
    • 51
    • 21
    • 18
    • 15
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Interferon gamma Antikörper ist unkonjugiert
    Applikation
    • 236
    • 210
    • 133
    • 98
    • 62
    • 44
    • 40
    • 38
    • 32
    • 30
    • 27
    • 25
    • 24
    • 22
    • 19
    • 14
    • 14
    • 11
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Radioimmunoassay (RIA)
    Spezifität
    The mouse monoclonal antibody 4S.B3 recognizes IFN-gamma, a 16-25 kDa cytokine produced by activated Th1 cells and NK cells. Binds both glycosylated and non-glycosylated protein.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Interferon gamma derived from human leukocytes
    Klon
    4S-B3
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product IFNG Primärantikörper
  • Applikationshinweise
    ELISA: This antibody is being used as detection antibody in combination with capture antibody NIB42.
    Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Janke, Witsch, Mages, Hutloff, Kroczek: "Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells." in: Immunology, Vol. 118, Issue 3, pp. 353-60, (2006) (PubMed).

    Caulfield, Fernandez, Sousa, Lane, Lee, Hawrylowicz: "Regulation of major histocompatibility complex class II antigens on human alveolar macrophages by granulocyte-macrophage colony-stimulating factor in the presence of glucocorticoids." in: Immunology, Vol. 98, Issue 1, pp. 104-10, (1999) (PubMed).

  • Target
    Interferon gamma (IFNG)
    Andere Bezeichnung
    IFN-gamma (IFNG Produkte)
    Synonyme
    IFG antikoerper, IFI antikoerper, IFN-g antikoerper, Ifg antikoerper, IFNG2 antikoerper, IFN-gamma antikoerper, IFN-G antikoerper, IFNG antikoerper, IFNgamma antikoerper, TCRalpha antikoerper, INF-G antikoerper, ifng antikoerper, interferon gamma antikoerper, interferon, gamma 1-2 antikoerper, IFNG antikoerper, Ifng antikoerper, ifng1-2 antikoerper
    Hintergrund
    Interferon gamma,The interferon gamma (IFN-gamma, 16-25 kDa) is an important regulator of the immune response, produced in activated Th1 cells and NK cells, particularly in response to IL-2, TNF-alpha and IL-12, its production is suppressed by IL-4, IL-10, and TGF-beta. The producing of IFN-gamma is activated by specific antigens or mitogens through the T cell antigen receptor. IFN-gamma polypeptide forms: 40-60 kDa forms are observable under non-denaturing conditions as dimers and trimers, 20 kDa and 25 kDa forms exist due to variable glycosylation. IFN-gamma belongs to the type II interferons, also called immune IFN. IFN-gamma shows antiviral activity and has important immunoregulatory functions. It is a potent activator of macrophages and had antiproliferative effects on transformed cells. IFN-gamma plays an important role in regulating B cell differentiation by simultaneously stimulating class switch recombination to the IgG3 and IgG2a isotypes while represing class switch recombination to the IgE and IgG1 isotypes. It also appears to promote antigen presentation by B cells through its effects on MHC. Binding of IFN-gamma to its receptor increases the expression of class I MHC on all somatic cells. It also enhances the expression of class II MHC on antigen-presenting cells. IFN-gamma is the major means by which T cells activate macrophages, increasing their ability to kill bacteria, parasites, and tumours. The activation of macrophages by IFN-gamma is essential for the elimination of bacteria that replicate within the phagosomes of macrophages (f.e. Mycobacteria and Listeria monocytogenes). IFN-gamma can potentiate the high antiviral and antitumor effects of the type I interferons (IFN-alpha, IFN-beta). IFN-gamma may also activate neutrophils and NK cells.,Interferon gamma, IFN-gamma
    Gen-ID
    3458
    UniProt
    P01579
    Pathways
    Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagie
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