CD84 Antikörper (APC)

Produktnummer ABIN2749140

Produktdetails anti-CD84 Antikörper (APC)

Target: CD84

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD84 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Spezifität: The mouse monoclonal antibody CD84.1.21 recognizes an extracellular epitope of CD84, a single chain cell surface glycoprotein of 64-82 kDa, predominantly expressed B cells, monocytes, platelets and some T cells.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: CD84-transfected 300.19 cell line

Klon: CD84-1-21

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Kommentare:

The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-CD84 Antikörper (APC) (ABIN2749140)

Romero, Zapater, Calvo, Kalko, de la Fuente, Tovar, Ockeloen, Pizcueta, Engel: "CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7033-42, (2005) (PubMed).

Morra, Lu, Poy, Martin, Sayos, Calpe, Gullo, Howie, Rietdijk, Thompson, Coyle, Denny, Yaffe, Engel, Eck, Terhorst: "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells." in: The EMBO journal, Vol. 20, Issue 21, pp. 5840-52, (2001) (PubMed).

Martin, Romero, de la Fuente, Tovar, Zapater, Esplugues, Pizcueta, Bosch, Engel: "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 7, pp. 3668-76, (2001) (PubMed).

Sayós, Martín, Chen, Simarro, Howie, Morra, Engel, Terhorst: "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP." in: Blood, Vol. 97, Issue 12, pp. 3867-74, (2001) (PubMed).

Details zu CD84

Target: CD84

Andere Bezeichnung: CD84 (CD84 Produkte)

Synonyme: RGD1564553 antikoerper, A130013D22Rik antikoerper, CDw84 antikoerper, SLAMF5 antikoerper, LY9B antikoerper, hCD84 antikoerper, mCD84 antikoerper, CD84 molecule antikoerper, CD84 antigen antikoerper, Cd84 antikoerper, CD84 antikoerper

Hintergrund: CD84 Molecule,CD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated.,LY9B, SLAMF5

Gen-ID: 8832

UniProt: Q9UIB8