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CD70 Antikörper (PE)

CD70 Reaktivität: Human FACS Wirt: Maus Monoclonal Ki-24 PE
Produktnummer ABIN2749173
  • Target Alle CD70 Antikörper anzeigen
    CD70 (CD70 Molecule (CD70))
    Reaktivität
    • 100
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 63
    • 36
    • 7
    • 2
    • 1
    Maus
    Klonalität
    • 64
    • 44
    • 1
    Monoklonal
    Konjugat
    • 53
    • 12
    • 11
    • 10
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD70 Antikörper ist konjugiert mit PE
    Applikation
    • 52
    • 48
    • 46
    • 41
    • 22
    • 19
    • 17
    • 14
    • 11
    • 9
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    human L428 cell line
    Klon
    Ki-24
    Isotyp
    IgG3 kappa
    Top Product
    Discover our top product CD70 Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Trebing, El-Mesery, Schäfer, Weisenberger, Siegmund, Silence, Wajant: "CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants." in: Cell death & disease, Vol. 5, pp. e1035, (2014) (PubMed).

    Hashimoto-Okada, Kitawaki, Kadowaki, Iwata, Morimoto, Hori, Uchiyama: "The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans." in: International immunology, Vol. 21, Issue 8, pp. 891-904, (2009) (PubMed).

    Kaufmann, Amariglio, Rosenthal, Hirsch, Many, Rechavi: "Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low-grade lymphoma." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 10, pp. 6940-7, (2005) (PubMed).

    Israel, Pickles, Segal, Gerard, Kenney: "Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody." in: Journal of virology, Vol. 75, Issue 11, pp. 5215-21, (2001) (PubMed).

  • Target
    CD70 (CD70 Molecule (CD70))
    Andere Bezeichnung
    CD70 (CD70 Produkte)
    Synonyme
    CD27LG antikoerper, Cd27l antikoerper, Tnfsf7 antikoerper, CD27L antikoerper, TNFSF7 antikoerper, CD70 antigen antikoerper, CD70 molecule antikoerper, Cd70 molecule antikoerper, Cd70 antikoerper, CD70 antikoerper
    Hintergrund
    CD70 Molecule,CD70, also known as TNFSF7 or CD27L, is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.,CD27L, TNFSF7, CD27 ligand, TNLG8A
    Gen-ID
    970
    UniProt
    P32970
    Pathways
    Cancer Immune Checkpoints
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