The mouse monoclonal antibody Ber-H8 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells, it is also found in Burkitt's lymphomas, virus-infected T and B lymphocytes, and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor).
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store at 2-8°C. Do not freeze.
Aalberse, Kapitein, de Roock, Klein, de Jager, van der Zee, Hoekstra, van Wijk, Prakken: "Cord blood CD4+ T cells respond to self heat shock protein 60 (HSP60)." in: PLoS ONE, Vol. 6, Issue 9, pp. e24119, (2011) (PubMed).
Matsumoto, Terakawa, Miura, Fukuda, Nakajima, Saito: "Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 4, pp. 2186-93, (2004) (PubMed).
Berro, Perry, Agrawal: "Increased expression and activation of CD30 induce apoptosis in human blood eosinophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 3, pp. 2174-83, (2004) (PubMed).
Franke, Jung, Ellis: "Characterization of the CD30L binding domain on the human CD30 molecule using anti-CD30 antibodies." in: Hybridoma, Vol. 19, Issue 1, pp. 43-8, (2000) (PubMed).
Falini, Pileri, Pizzolo, Dürkop, Flenghi, Stirpe, Martelli, Stein: "CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy." in: Blood, Vol. 85, Issue 1, pp. 1-14, (1995) (PubMed).
Target
TNFRSF8
(Tumor Necrosis Factor Receptor Superfamily, Member 8 (TNFRSF8))
CD30 antikoerper, D1S166E antikoerper, Ki-1 antikoerper, Cd30 antikoerper, Ki antikoerper, TNFRSF8 antikoerper, TNF receptor superfamily member 8 antikoerper, tumor necrosis factor receptor superfamily, member 8 antikoerper, TNFRSF8 antikoerper, Tnfrsf8 antikoerper
Hintergrund
TNF receptor superfamily member 8,CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response.,Ki-1, TNFRSF8, CD30L receptor, D1S166E