Cadherin 5 Antikörper

Produktnummer ABIN2749192

Produktdetails anti-Cadherin 5 Antikörper

Target: Cadherin 5 (CDH5)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cadherin 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: The mouse monoclonal antibody 55-7H1 recognizes a calcium-independent extracellular epitope on CD144 (VE-cadherin, cadherin 5), an adhesion molecule expressed on endothelial cells.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Human endothelial cells

Klon: 55-7H1

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-Cadherin 5 Antikörper (ABIN2749192)

Hamilton, Foss, Leach: "Establishment of a human in vitro model of the outer blood-retinal barrier." in: Journal of anatomy, Vol. 211, Issue 6, pp. 707-16, (2007) (PubMed).

Limaye, Li, Hahn, Xia, Berndt, Vadas, Gamble: "Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members." in: Blood, Vol. 105, Issue 8, pp. 3169-77, (2005) (PubMed).

Details zu Cadherin 5

Target: Cadherin 5 (CDH5)

Andere Bezeichnung: CD144 (CDH5 Produkte)

Synonyme: 7B4 antikoerper, AA408225 antikoerper, Cd144 antikoerper, VE-Cad antikoerper, VECD antikoerper, VEcad antikoerper, Vec antikoerper, wu:fc88a07 antikoerper, CD144 antikoerper, cadherin-5 antikoerper, cadherin 5 antikoerper, CDH5 antikoerper, Cdh5 antikoerper, cdh5 antikoerper

Hintergrund: Cadherin 5,CD144 / VE-cadherin (cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (delta1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability.,Cadherin 5, CDH5, 7B4, VE-cadherin

Gen-ID: 1003

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2