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TRAIL Antikörper (AA 95-281)
TNFSF10
Reaktivität: Human
FACS
Wirt: Maus
Monoclonal
2E5
unconjugated
Produktnummer ABIN2751999
Produktdetails anti-TRAIL Antikörper
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Target
Alle TRAIL (TNFSF10) Antikörper anzeigen
TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Bindungsspezifität
Alle Epitope für TRAIL Antikörper
AA 95-281
Reaktivität
Alle Reaktivitäten für TRAIL Antikörper
Human
Wirt
Alle Wirte für TRAIL Antikörper
Maus
Klonalität
Alle Klonalitäten für TRAIL Antikörper
Monoklonal
Konjugat
Alle Konjugate für TRAIL Antikörper
Dieser TRAIL Antikörper ist unkonjugiert
Applikation
Alle Applikationen für TRAIL Antikörper
Flow Cytometry (FACS)
Spezifität
The antibody 2E5 reacts with an extracellular epitope within C-terminal half of TRAIL (APO-2L), a 21 kDa cytotoxic protein, activator of rapid apoptosis in tumor cells. TRAIL is mainly expressed in spleen, lung, prostate and also in many other tissues.
Keine Kreuzreaktivität
Maus
Kreuzreaktivität (Details)
Human
Aufreinigung
Purified by protein-A affinity chromatography.
Reinheit
> 95 % (by SDS-PAGE)
Immunogen
Recombinant soluble fragment (aa 95-281) of human TRAIL.
Klon
2E5
Isotyp
IgG1
Top Product
Discover our top product TNFSF10 Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Flow cytometry: Recommended dilution: 1-5 μg/mL.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store at 2-8°C. Do not freeze.
Referenzen für anti-TRAIL Antikörper (ABIN2751999)
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Hyer, Croxton, Krajewska, Krajewski, Kress, Lu, Suh, Sporn, Cryns, Zapata, Reed : "Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. " in: Cancer research , Vol. 65 , Issue 11 , pp. 4799-808 , (2005 ) (PubMed ).
Plasilova, Zivny, Jelinek, Neuwirtova, Cermak, Necas, Andera, Stopka : "TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. " in: Leukemia , Vol. 16 , Issue 1 , pp. 67-73 , (2002 ) (PubMed ).
Details zu TRAIL
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Target
TRAIL (TNFSF10)
(Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
Andere Bezeichnung
CD253 / TRAIL (TNFSF10 Produkte )
Synonyme
APO2L antikoerper, Apo-2L antikoerper, CD253 antikoerper, TL2 antikoerper, TRAIL antikoerper, A330042I21Rik antikoerper, AI448571 antikoerper, APO-2L antikoerper, Ly81 antikoerper, Trail antikoerper, tl2 antikoerper, apo2l antikoerper, cd253 antikoerper, trail antikoerper, apo-2l antikoerper, trail1 antikoerper, xtrail1 antikoerper, tnfsf10l2 antikoerper, zgc:92320 antikoerper, TNLG6A antikoerper, TNF superfamily member 10 antikoerper, tumor necrosis factor (ligand) superfamily, member 10 antikoerper, tumor necrosis factor superfamily member 10 antikoerper, TNF superfamily member 10 S homeolog antikoerper, TNFSF10 antikoerper, Tnfsf10 antikoerper, tnfsf10.S antikoerper, tnfsf10 antikoerper
Hintergrund
TNF superfamily member 10,Human CD253 / TRAIL (TNF-related apoptosis inducing ligand), also called Apo2, is a type II membrane protein from the TNF family. TRAIL is a cytotoxic protein which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apotosis, is achieved through binding to two dealth-signaling receptors, DR4 (CD261 / TRAIL-R1) and DR5 (CD262 / TRAIL-R2).,TRAIL, Apo-2 ligand, Apo-2L, TNFSF10, APO2L, TNLG6A
Gen-ID
8743
UniProt
P50591
Pathways
Apoptose , Positive Regulation of Endopeptidase Activity
Zuletzt angesehen
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