hCoV-OC43 Spike Antikörper (AA 15-344)

Produktnummer ABIN2754654

Produktdetails anti-hCoV-OC43 Spike Antikörper

Target: hCoV-OC43 Spike (HCoV-OC43 S) (Coronavirus OC43 Spike Protein (HCoV-OC43 S))

Bindungsspezifität: AA 15-344

Reaktivität: Human Coronavirus OC43 (HCoV-OC43)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser hCoV-OC43 Spike Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Aufreinigung: Caprylic Acid Ammonium Sulfate Precipitation

Immunogen: Recombinant Human coronavirus OC43 Spike glycoprotein protein(15-344aa)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C/-80 °C

Referenzen für anti-hCoV-OC43 Spike Antikörper (ABIN2754654)

Kim, Jeong, Yu, Shin, Ku, Cha, Han, Hong, Kim, Kim, Woo, Bae: "Efficient Human Cell Coexpression System and Its Application to the Production of Multiple Coronavirus Antigens." in: Advanced biology, Vol. 5, Issue 4, pp. e2000154, (2021) (PubMed).

Wang, Li, Zhou, Wiltse, Zand: "Antibody Mediated Immunity to SARS-CoV-2 and Human Coronaviruses: Multiplex Beads Assay and Volumetric Absorptive Microsampling to Generate Immune Repertoire Cartography." in: Frontiers in immunology, Vol. 12, pp. 696370, (2021) (PubMed).

Min, Kim, Jin, Kwon: "Kurarinone Inhibits HCoV-OC43 Infection by Impairing the Virus-Induced Autophagic Flux in MRC-5 Human Lung Cells." in: Journal of clinical medicine, Vol. 9, Issue 7, (2020) (PubMed).

Details zu hCoV-OC43 Spike

Target: hCoV-OC43 Spike (HCoV-OC43 S) (Coronavirus OC43 Spike Protein (HCoV-OC43 S))

Andere Bezeichnung: OC43 Spike Glycoprotein (HCoV-OC43 S Produkte)

Substanzklasse: Viral Protein

Hintergrund: S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

UniProt: P36334