OTC Antikörper (N-Term)
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- Target Alle OTC Antikörper anzeigen
- OTC (Ornithine Carbamoyltransferase (OTC))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Schwein, Schaf, Kaninchen, Ziege, Meerschweinchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser OTC Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- AFRNGHNFMV RNFRCGQPLQ NKVQLKGRDL LTLKNFTGEE IKYMLWLSAD
- Homologie
- Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against OTC. It was validated on Western Blot and immunohistochemistry.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human OTC
- Top Product
- Discover our top product OTC Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 354 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction." in: Molecular cell, Vol. 41, Issue 2, pp. 139-49, (2011) (PubMed).
: "Urea cycle gene expression is suppressed by PFOA treatment in rats." in: Toxicology letters, Vol. 197, Issue 1, pp. 46-50, (2010) (PubMed).
: "Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13669-75, (2009) (PubMed).
: "Hyperammonemia-induced encephalopathy due to ornithine transcarbamylase deficiency in an adult woman: identification of novel missense mutations." in: Journal of gastroenterology, Vol. 40, Issue 1, pp. 106-7, (2005) (PubMed).
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Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction." in: Molecular cell, Vol. 41, Issue 2, pp. 139-49, (2011) (PubMed).
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- Target
- OTC (Ornithine Carbamoyltransferase (OTC))
- Andere Bezeichnung
- OTC (OTC Produkte)
- Synonyme
- OCTD antikoerper, 2810428A13Rik antikoerper, AA589422 antikoerper, AW457381 antikoerper, OCT antikoerper, Plxn2 antikoerper, mKIAA0463 antikoerper, F1B16.13 antikoerper, F1B16_13 antikoerper, ORNITHINE CARBAMOYLTRANSFERASE antikoerper, ornithine carbamoyltransferase antikoerper, BA4351 antikoerper, PSPTO4164 antikoerper, PLXN2 antikoerper, AI265390 antikoerper, Sf antikoerper, spf antikoerper, si:dkey-19h21.3 antikoerper, ornithine carbamoyltransferase antikoerper, plexin A2 antikoerper, ornithine carbamoyltransferase ArgF antikoerper, ornithine transcarbamylase antikoerper, OTC antikoerper, Plxna2 antikoerper, Otc antikoerper, argF antikoerper, argF-2 antikoerper, atpD-2 antikoerper, CNC04300 antikoerper, PLXNA2 antikoerper, otc antikoerper
- Hintergrund
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OTC is a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.
Alias Symbols: OCTD
Protein Interaction Partner: OTC, TOMM20,
Protein Size: 354 - Molekulargewicht
- 39 kDa
- Gen-ID
- 5009
- NCBI Accession
- NM_000531, NP_000522
- UniProt
- P00480
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