C1QB Antikörper (C-Term)

Produktnummer ABIN2773842

Produktdetails anti-C1QB Antikörper

Target: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Bindungsspezifität: C-Term

Reaktivität: Human, Hund, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C1QB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: AYNTFQVTTG GMVLKLEQGE NVFLQATDKN SLLGMEGANS IFSGFLLFPD

Homologie: Dog: 92%, Horse: 82%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against C1QB. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human C1QB

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 253 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-C1QB Antikörper (ABIN2773842)

Takamori, Atsuta, Nakamura, Sawase, Koyano, Hara: "Histopathological comparison of the onset of peri-implantitis and periodontitis in rats." in: Clinical oral implants research, Vol. 28, Issue 2, pp. 163-170, (2016) (PubMed).

Noguchi, Ukai, Kuramoto, Yoshinaga, Nakamura, Takamori, Yamashita, Hara: "The histopathological comparison on the destruction of the periodontal tissue between normal junctional epithelium and long junctional epithelium." in: Journal of periodontal research, Vol. 52, Issue 1, pp. 74-82, (2016) (PubMed).

Nakatsu, Yoshinaga, Kuramoto, Nagano, Ichimura, Oshino, Yoshimura, Yano, Hara: "Occlusal trauma accelerates attachment loss at the onset of experimental periodontitis in rats." in: Journal of periodontal research, Vol. 49, Issue 3, pp. 314-22, (2014) (PubMed).

Nagano, Kaneko, Yoshinaga, Ukai, Kuramoto, Nakatsu, Oshino, Ichimura, Hara: "Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction." in: Journal of periodontal research, Vol. 48, Issue 4, pp. 420-7, (2013) (PubMed).

Kuramoto, Yoshinaga, Kaneko, Ukai, Shiraishi, Oshino, Ichimura, Hara: "The formation of immune complexes is involved in the acute phase of periodontal destruction in rats." in: Journal of periodontal research, Vol. 47, Issue 4, pp. 455-62, (2012) (PubMed).

Yoshinaga, Ukai, Kaneko, Nakatsu, Shiraishi, Kuramoto, Oshino, Ichimura, Hara: "Topical application of lipopolysaccharide into gingival sulcus promotes periodontal destruction in rats immunized with lipopolysaccharide." in: Journal of periodontal research, Vol. 47, Issue 5, pp. 674-80, (2012) (PubMed).

Details zu C1QB

Target: C1QB (Complement Component 1, Q Subcomponent, B Chain (C1QB))

Andere Bezeichnung: C1QB (C1QB Produkte)

Synonyme: complement C1q B chain antikoerper, complement component 1, q subcomponent, beta polypeptide antikoerper, C1QB antikoerper, C1qb antikoerper

Hintergrund: C1QB is a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. C1QB is the B-chain polypeptide of human complement subcomponent C1q.This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q.
Alias Symbols: -
Protein Interaction Partner: IL32, EED, FN1, EDA2R, RELA, MYOC, PTX3, C1R, HRG, DEFA1, C1QC, C1QA,
Protein Size: 253

Molekulargewicht: 27 kDa

Gen-ID: 713

NCBI Accession: NM_000491, NP_000482

UniProt: P02746

Pathways: Komplementsystem