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HSD11B1 Antikörper (N-Term)

HSD11B1 Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Schaf, Rind (Kuh), Pferd, Meerschweinchen WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2773867
  • Target Alle HSD11B1 Antikörper anzeigen
    HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
    Bindungsspezifität
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    Human, Maus, Ratte, Hund, Kaninchen, Schaf, Rind (Kuh), Pferd, Meerschweinchen
    Wirt
    • 42
    • 6
    • 2
    Kaninchen
    Klonalität
    • 39
    • 11
    Polyklonal
    Konjugat
    • 29
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser HSD11B1 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 15
    • 13
    • 8
    • 7
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequenz
    QKVVSHCLEL GAASAHYIAG TMEDMTFAEQ FVAQAGKLMG GLDMLILNHI
    Homologie
    Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 93%
    Produktmerkmale
    This is a rabbit polyclonal antibody against HSD11B1. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B1
    Top Product
    Discover our top product HSD11B1 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 292 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Kuroda, Venkatakrishnan, Salker, Lucas, Shaheen, Kuroda, Blanks, Christian, Quenby, Brosens: "Induction of 11?-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 2, pp. 192-202, (2013) (PubMed).

    Lei, Chen, Georgiou, Sooranna, Khanjani, Brosens, Bennett, Johnson: "Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1?-induced COX-2 expression in human term myometrial cells." in: PLoS ONE, Vol. 7, Issue 11, pp. e50167, (2012) (PubMed).

  • Target
    HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
    Andere Bezeichnung
    HSD11B1 (HSD11B1 Produkte)
    Synonyme
    11-DH antikoerper, 11-beta-HSD1 antikoerper, CORTRD2 antikoerper, HDL antikoerper, HSD11 antikoerper, HSD11B antikoerper, HSD11L antikoerper, SDR26C1 antikoerper, hsd11 antikoerper, hsd11b antikoerper, LRRGT00065 antikoerper, hydroxysteroid 11-beta dehydrogenase 1 antikoerper, hydroxysteroid (11-beta) dehydrogenase 1b antikoerper, hydroxysteroid (11-beta) dehydrogenase 1 L homeolog antikoerper, HSD11B1 antikoerper, HSD11B1b antikoerper, hsd11b1.L antikoerper, Hsd11b1 antikoerper
    Hintergrund
    HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
    Alias Symbols: 11-DH, 11-beta-HSD1, HDL, HSD11, HSD11B, HSD11L, MGC13539, SDR26C1
    Protein Interaction Partner: GKAP1, CD36,
    Protein Size: 292
    Molekulargewicht
    32 kDa
    Gen-ID
    3290
    NCBI Accession
    NM_005525, NP_005516
    UniProt
    P28845
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process
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