MRVI1 Antikörper (N-Term)

Produktnummer ABIN2773963

Produktdetails anti-MRVI1 Antikörper

Target: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Bindungsspezifität: N-Term

Reaktivität: Human, Rind (Kuh), Hund, Meerschweinchen, Pferd, Maus, Kaninchen, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MRVI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MRVI1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human MRVI1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MRVI1

Target: MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))

Andere Bezeichnung: MRVI1 (MRVI1 Produkte)

Synonyme: BB115629 antikoerper, Irag antikoerper, Ris1 antikoerper, IRAG antikoerper, JAW1L antikoerper, MRV integration site 1 antikoerper, murine retrovirus integration site 1 homolog antikoerper, Mrvi1 antikoerper, MRVI1 antikoerper

Hintergrund: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
Protein Interaction Partner: MME, PRKG1, ITPR1,
Protein Size: 803

Molekulargewicht: 88 kDa

Gen-ID: 10335