FZR1 Antikörper (N-Term)

Produktnummer ABIN2773984

Produktdetails anti-FZR1 Antikörper

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FZR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RQIIIQNENT VPCVSEMRRT LTPANSPVSS PSKHGDRFIP SRAGANWSVN

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%, Zebrafish: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against Fzr1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 493 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FZR1

Target: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Andere Bezeichnung: Fzr1 (FZR1 Produkte)

Synonyme: CDH1-C antikoerper, FYR antikoerper, FZR antikoerper, CDH1 antikoerper, fzr1 antikoerper, CDC20C antikoerper, FZR2 antikoerper, HCDH antikoerper, HCDH1 antikoerper, AW108046 antikoerper, Cdh1 antikoerper, Fyr antikoerper, zgc:55450 antikoerper, fizzy and cell division cycle 20 related 1 antikoerper, fizzy/cell division cycle 20 related 1 antikoerper, fizzy-related protein homolog antikoerper, fizzy/cell division cycle 20 related 1 (Drosophila) antikoerper, fizzy/cell division cycle 20 related 1a antikoerper, Fzr1 antikoerper, CDH1-C antikoerper, FZR1 antikoerper, LOC100027495 antikoerper, LOC100179951 antikoerper, fzr1a antikoerper

Hintergrund: Fzr1 is the key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Fzr1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alias Symbols: AW108046, Cdh1, FZR, FZR2, Fyr, HCDH, HCDH1
Protein Interaction Partner: Arhgap35, Rrm2, Ccnb1, Cdc27, Sirt2, Smurf1, Skil, Ube2c, Csf3r,
Protein Size: 493

Molekulargewicht: 55 kDa

Gen-ID: 56371

NCBI Accession: NM_019757, NP_062731

UniProt: Q9R1K5

Pathways: DNA Replication, Synthesis of DNA