OAS1 Antikörper (Middle Region)

Produktnummer ABIN2773987

Produktdetails anti-OAS1 Antikörper

Target: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OAS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: RRQLTKPRPV ILDPADPTGN LGGGDPKGWR QLAQEAEAWL NYPCFKNWDG

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 87%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 86%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against OAS1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human OAS1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 414 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-OAS1 Antikörper (ABIN2773987)

Yu, Yan, Liu, Li, Liu, Zhu, Chen, Han: "Pattern recognition receptor-initiated innate antiviral response in mouse adipose cells." in: Immunology and cell biology, Vol. 92, Issue 2, pp. 105-15, (2014) (PubMed).

Zhu, Chen, Yan, Liu, Li, Zhang, Yu, Chen, Han: "RIG-I-like receptors mediate innate antiviral response in mouse testis." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 9, pp. 1455-67, (2013) (PubMed).

Details zu OAS1

Target: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Andere Bezeichnung: OAS1 (OAS1 Produkte)

Synonyme: OAS1 antikoerper, IFI-4 antikoerper, OIAS antikoerper, OIASI antikoerper, L3 antikoerper, Pp2a2 antikoerper, 2',5'-oligoadenylate synthetase 1 antikoerper, 2'-5'-oligoadenylate synthetase 1 antikoerper, 2'-5' oligoadenylate synthetase 1A antikoerper, protein phosphatase 2 catalytic subunit beta antikoerper, OAS1 antikoerper, Oas1a antikoerper, Ppp2cb antikoerper, Oas1 antikoerper

Hintergrund: This protein is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: IFI-4, OIAS, OIASI
Protein Interaction Partner: EXOC5, TRIM27, ACTN1, PRMT6, WBSCR22, RPL30, HCVgp1,
Protein Size: 414

Molekulargewicht: 47 kDa

Gen-ID: 4938

NCBI Accession: NM_001032409, NP_001027581

Pathways: Hepatitis C