FRS3 Antikörper (Middle Region)

Produktnummer ABIN2774008

Produktdetails anti-FRS3 Antikörper

Target: FRS3 (Fibroblast Growth Factor Receptor Substrate 3 (FRS3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Hund, Pferd, Kaninchen, Rind (Kuh), Meerschweinchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FRS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GFPDGEEDET PLQKPTSTRA AIRSHGSFPV PLTRRRGSPR VFNFDFRRPG

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against FRS3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FRS3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 492 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FRS3

Target: FRS3 (Fibroblast Growth Factor Receptor Substrate 3 (FRS3))

Andere Bezeichnung: FRS3 (FRS3 Produkte)

Hintergrund: FRS3 is an adapter protein that links FGR and NGF receptors to downstream signaling pathways. FRS3 is involved in the activation of MAP kinases. FRS3 down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FRS2B, FRS2beta, MGC17167, SNT-2, SNT2
Protein Interaction Partner: NOTCH2NL, RFX6, SPERT, ADAMTSL4, SH3KBP1, CD2AP, SPRY2, TRIP6, TCF4, PLSCR1, GATA1, ERBB2, CBL, AES, ELAVL1, RND1, KARS, BMPR2, NTRK2, PRKCI, NTRK1, MAPK1, PTPN11, FGFR1, GRB2,
Protein Size: 492

Molekulargewicht: 54 kDa

Gen-ID: 10817

NCBI Accession: NM_006653, NP_006644

UniProt: O43559