CAMKK2 Antikörper (N-Term)

Produktnummer ABIN2774040

Produktdetails anti-CAMKK2 Antikörper

Target: CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Schwein, Meerschweinchen, Kaninchen, Rind (Kuh), Hund, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CAMKK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GGLAAGGSLD MNGRCICPSL PYSPVSSPQS SPRLPRRPTV ESHHVSITGM

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 86%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against CAMKK2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CAMKK2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 498 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CAMKK2

Target: CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))

Andere Bezeichnung: CAMKK2 (CAMKK2 Produkte)

Synonyme: CAMKK antikoerper, CAMKKB antikoerper, 6330570N16Rik antikoerper, AW061083 antikoerper, mKIAA0787 antikoerper, camk2b antikoerper, fj90d04 antikoerper, wu:fj90d04 antikoerper, si:dkey-174n20.2 antikoerper, CAMKK2 antikoerper, calcium/calmodulin dependent protein kinase kinase 2 antikoerper, calcium/calmodulin-dependent protein kinase kinase 2, beta antikoerper, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 antikoerper, calcium/calmodulin dependent protein kinase II beta antikoerper, calcium/calmodulin-dependent protein kinase kinase 2 antikoerper, CAMKK2 antikoerper, Camkk2 antikoerper, camk2b1 antikoerper, CAMK2B antikoerper, camkk2 antikoerper

Hintergrund: CAMKK2 is a calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 seems to be involved in hippocampal activation of CREB1.The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this gene. Additional splice variants have been described but their full-length nature has not been determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and to phosphorylate the downstream kinases.
Alias Symbols: CAMKK, CAMKKB, KIAA0787, MGC15254
Protein Interaction Partner: HSP90AA1, APP, UBC, NEDD4, CEP63, ESYT2, FANCI, OBSL1, ATG4B, XPOT, GCN1L1, IQGAP2, SMC3, SLC25A11, SMC1A, PRKDC, PRKAG1, PRKAA2, IRAK1, FLNC, FLNA, MAPK14, CALM1, CAMK4, CAMK1, PRKACA, SGK1,
Protein Size: 498

Molekulargewicht: 55 kDa

Gen-ID: 10645

NCBI Accession: NM_153500, NP_705720

UniProt: Q96RR4

Pathways: AMPK Signaling