COPS4 Antikörper (Middle Region)

Produktnummer ABIN2774165

Produktdetails anti-COPS4 Antikörper

Target: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COPS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: YKLETYLKIA RLYLEDDDPV QAEAYINRAS LLQNESTNEQ LQIHYKVCYA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against COPS4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COPS4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 406 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-COPS4 Antikörper (ABIN2774165)

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Details zu COPS4

Target: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Andere Bezeichnung: COPS4 (COPS4 Produkte)

Synonyme: CG8725 antikoerper, CH4 antikoerper, Cops4 antikoerper, Csn4 antikoerper, DCH4 antikoerper, Dch4 antikoerper, Dmel\\CG8725 antikoerper, csn4 antikoerper, l(2)k08018 antikoerper, COPS4 antikoerper, SGN4 antikoerper, DKFZp459H0324 antikoerper, AW208976 antikoerper, D5Ertd774e antikoerper, fc90c08 antikoerper, wu:fc90c08 antikoerper, zgc:77137 antikoerper, ATS4 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 14 antikoerper, CONSTITUTIVE PHOTOMORPHOGENIC 8 antikoerper, COP14 antikoerper, COP9 SIGNALOSOME SUBUNIT 4 antikoerper, CSN4 antikoerper, EMB134 antikoerper, EMBRYO DEFECTIVE 134 antikoerper, FUS4 antikoerper, FUS8 antikoerper, FUSCA 4 antikoerper, FUSCA 8 antikoerper, MBD2.17 antikoerper, MBD2_17 antikoerper, COS41.8 antikoerper, COP9 signalosome subunit 4 antikoerper, COP9 signalosome complex subunit 4 antikoerper, COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antikoerper, Proteasome component (PCI) domain protein antikoerper, COP9 signalosome subunit 4 L homeolog antikoerper, CSN4 antikoerper, COPS4 antikoerper, CpipJ_CPIJ000966 antikoerper, csn4 antikoerper, Cops4 antikoerper, cops4 antikoerper, COP8 antikoerper, cops4.L antikoerper, csn-4 antikoerper

Hintergrund: COPS4 is one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MGC10899, MGC15160, CSN4
Protein Interaction Partner: USHBP1, GPS1, UBC, Skp2, PRMT5, KPNA2, HSP90AB1, EPB41L2, EPB41L1, CAST, WDR77, ENAH, DCAF8, COPS5, STIP1, COPS6, YWHAQ, FOS, COPS8, COPS7A, FBXO6, BAG3, FBXW4, vpr, IRF5, COPS7B, COPS2, COPS3, TOR1AIP2, LRR1, FBXO17, DCAF11, DDA1, RFWD2, KLHL42, GRK5, DD
Protein Size: 406

Molekulargewicht: 46 kDa

Gen-ID: 51138

NCBI Accession: NM_016129, NP_057213

UniProt: Q9BT78

Pathways: Zellzyklus