CNTF Receptor alpha Antikörper (C-Term)

Produktnummer ABIN2774276

Produktdetails anti-CNTF Receptor alpha Antikörper

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Hund, Pferd, Meerschweinchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNTF Receptor alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: VAAHATPWTE EPRHLTTEAQ AAETTTSTTS SLAPPPTTKI CDPGELGSGG

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Sheep: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CNTFR. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CNTFR

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 372 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CNTF Receptor alpha

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Andere Bezeichnung: CNTFR (CNTFR Produkte)

Synonyme: CNTFR-alpha antikoerper, CNTFRALPHA antikoerper, Cntfralpha antikoerper, cb549 antikoerper, fj33e02 antikoerper, sb:cb549 antikoerper, wu:fj33e02 antikoerper, si:bz76a6.1 antikoerper, si:dz248f2.1 antikoerper, si:rp71-76a6.1 antikoerper, ciliary neurotrophic factor receptor antikoerper, ciliary neurotrophic factor receptor L homeolog antikoerper, CNTFR antikoerper, cntfr.L antikoerper, Cntfr antikoerper, cntfr antikoerper

Hintergrund: This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
Alias Symbols: MGC1774
Protein Interaction Partner: HN1L, KRTAP4-12, CLCF1, CRLF1, PLSCR1, APPBP2, IL6ST, LIFR, CNTF,
Protein Size: 372

Molekulargewicht: 41 kDa

Gen-ID: 1271

NCBI Accession: NM_001842, NP_001833

UniProt: P26992

Pathways: JAK-STAT Signalweg, Feeding Behaviour