FBXO2 Antikörper (C-Term)
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- Target Alle FBXO2 Antikörper anzeigen
- FBXO2 (F-Box Protein 2 (FBXO2))
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Bindungsspezifität
- C-Term
- Reaktivität
- Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Meerschweinchen, Zebrafisch (Danio rerio), Kaninchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FBXO2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- LAEFATGQVA VPEDGSWMEI SHTFIDYGPG VRFVRFEHGG QDSVYWKGWF
- Homologie
- Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 93%, Zebrafish: 77%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Fbxo2. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Top Product
- Discover our top product FBXO2 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 297 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- FBXO2 (F-Box Protein 2 (FBXO2))
- Andere Bezeichnung
- Fbxo2 (FBXO2 Produkte)
- Synonyme
- FBG1 antikoerper, FBX2 antikoerper, Fbs1 antikoerper, NFB42 antikoerper, OCP1 antikoerper, Fbs2 antikoerper, Prpl4 antikoerper, F-box protein 2 antikoerper, FBXO2 antikoerper, Fbxo2 antikoerper
- Hintergrund
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Fbxo2 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
Alias Symbols: FBG1, FBX2, Fbs1, Fbs2, MGC54895, NFB42, Prpl4
Protein Interaction Partner: Stat1, Cul1, Skp1a, Bace1, Vcp,
Protein Size: 297 - Molekulargewicht
- 34 kDa
- Gen-ID
- 230904
- NCBI Accession
- NM_176848, NP_789818
- UniProt
- Q80UW2
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