UBR2 Antikörper (C-Term)

Produktnummer ABIN2774730

Produktdetails anti-UBR2 Antikörper

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Hund, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QGLRRGNPLH LCKERFKKIQ KLWHQHSVTE EIGHAQEANQ TLVGIDWQHL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against UBR2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human UBR2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1755 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu UBR2

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Andere Bezeichnung: UBR2 (UBR2 Produkte)

Synonyme: ba49a4.1 antikoerper, si:ch211-239i4.2 antikoerper, C6orf133 antikoerper, RP3-392M17.3 antikoerper, bA49A4.1 antikoerper, dJ242G1.1 antikoerper, dJ392M17.3 antikoerper, 9930021A08Rik antikoerper, AI462103 antikoerper, AW540746 antikoerper, E130209G04Rik antikoerper, mKIAA0349 antikoerper, ubiquitin protein ligase E3 component n-recognin 2 antikoerper, ubiquitin protein ligase E3 component n-recognin 2 S homeolog antikoerper, UBR2 antikoerper, ubr2 antikoerper, ubr2.S antikoerper, Ubr2 antikoerper

Hintergrund: Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron.Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM].
Alias Symbols: C6orf133, DKFZp686C08114, KIAA0349, MGC71112, RP3-392M17.3, bA49A4.1, dJ242G1.1, dJ392M17.3
Protein Interaction Partner: vif, UBC, UBE2H, RECQL4, HIST1H2BG, HIST2H2AC, TIRAP, UBE2Z, UBXN1, UBXN7, FAF2, FAF1, UBE2B, MYC, HNRNPA1,
Protein Size: 1755

Molekulargewicht: 200 kDa

Gen-ID: 23304

NCBI Accession: NM_015255, NP_056070

UniProt: Q8IWV8