STUB1 Antikörper (C-Term)

Produktnummer ABIN2774917

Produktdetails anti-STUB1 Antikörper

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Hund, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STUB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: VDEKRKKRDI PDYLCGKISF ELMREPCITP SGITYDRKDI EEHLQRVGHF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against STUB1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human STUB1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 303 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu STUB1

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Andere Bezeichnung: STUB1 (STUB1 Produkte)

Hintergrund: STUB1 modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. STUB1 mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
Alias Symbols: CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1
Protein Interaction Partner: HSP90AA1, HSPA8, PCSK9, OLFM3, ATCAY, CCL28, UBE2Q1, TXN2, RUSC1, HSPA1B, FMR1, ERN1, STUB1, UBE2V1, UBE2N, UBE2D3, UBE2D1, UBC, TP53, MAPT, MAP3K11, SNAI2, BAG1, HSPA4L, CDC37, DNAJB6, BAG2, BAG3, BAG4, MLF2, HSP90AB1, HSPA4, HSPA2, HSPA1L, ENDOG, TXLNG,
Protein Size: 303

Molekulargewicht: 35 kDa

Gen-ID: 10273

NCBI Accession: NM_005861, NP_005852

UniProt: Q9UNE7

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation