DDX5 Antikörper (C-Term)

Produktnummer ABIN2775191

Produktdetails anti-DDX5 Antikörper

Target: DDX5 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 5 (DDX5))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SFGSNFVSAG IQTSFRTGNP TGTYQNGYDS TQQYGSNVPN MHNGMNQQAY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DDX5. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DDX5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 614 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-DDX5 Antikörper (ABIN2775191)

Huang, Chen, Wu, Huang, He, Tang, Wang, Wang: "The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 12, pp. 4901-13, (2015) (PubMed).

Naji, Ambrus, Cimerman?i?, Reyes, Johnson, Filbrandt, Huber, Vesely, Krogan, Yates, Saphire, Gerace: "Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 4, pp. M111.015313, (2012) (PubMed).

Details zu DDX5

Target: DDX5 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 5 (DDX5))

Andere Bezeichnung: DDX5 (DDX5 Produkte)

Synonyme: G17P1 antikoerper, HLR1 antikoerper, HUMP68 antikoerper, p68 antikoerper, 2600009A06Rik antikoerper, Hlr1 antikoerper, wu:fa56a07 antikoerper, wu:fb11e01 antikoerper, wu:fb16c10 antikoerper, wu:fb53b05 antikoerper, ddx5 antikoerper, DEAD-box helicase 5 antikoerper, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 antikoerper, DEAD (Asp-Glu-Ala-Asp) box helicase 5 antikoerper, DEAD-box helicase 5 L homeolog antikoerper, DDX5 antikoerper, Ddx5 antikoerper, ddx5 antikoerper, ddx5.L antikoerper

Hintergrund: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX5 encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. DDX5 consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.
Alias Symbols: p68, HLR1, G17P1, HUMP68
Protein Interaction Partner: FUS, ESR1, DROSHA, MAPKAPK2, UBC, TP53, TUBGCP3, AURKB, SPRTN, AURKA, SUMO2, SUMO3, MDM2, CEP250, STAU1, RPA3, RPA2, RPA1, EED, EZH2, RNF2, SUZ12, rev, DDX17, PABPC4, PRPSAP1, PIN1, LRSAM1, FKBP10, ERO1L, DBNL, WDR4, PARK2, FBXO6, MAPK10, SP1, TARDBP, UBD
Protein Size: 614

Molekulargewicht: 68 kDa

Gen-ID: 1655

NCBI Accession: NM_004396, NP_004387

UniProt: P17844

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Response to DNA Damage Stimulus