Perforin 1 Antikörper (N-Term)

Produktnummer ABIN2775294

Produktdetails anti-Perforin 1 Antikörper

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Pferd, Hund, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Perforin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SVAGSHSQAA NFAAQKTHQD QYSFSTDTVE CRFYSFHVVH TPPLHPDFKR

Homologie: Cow: 77%, Dog: 92%, Guinea Pig: 77%, Horse: 85%, Human: 100%, Pig: 100%, Rabbit: 92%, Rat: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against PRF1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PRF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 555 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Perforin 1

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Andere Bezeichnung: PRF1 (PRF1 Produkte)

Hintergrund: PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FLH2, HPLH2, MGC65093, P1, PFP, PFN1
Protein Interaction Partner: KRT31, FBXO6, PRF1, TRIM54, DDX24, GZMB, CALR,
Protein Size: 555

Molekulargewicht: 59 kDa

Gen-ID: 5551

NCBI Accession: NM_005041, NP_005032

UniProt: P14222

Pathways: Apoptose, Caspase Kaskade in der Apoptose