SLC1A5 Antikörper (Middle Region)

Produktnummer ABIN2775316

Produktdetails anti-SLC1A5 Antikörper

Target: SLC1A5 (Solute Carrier Family 1 Member 5 (SLC1A5))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Schaf, Pferd, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC1A5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: FGVALRKLGP EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against SLC1A5. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SLC1A5

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 541 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SLC1A5 Antikörper (ABIN2775316)

Qiu, Qin, Luo, Zhang, Sun, Jiao, Li, Yin: "Protein Restriction with Amino Acid-Balanced Diets Shrinks Circulating Pool Size of Amino Acid by Decreasing Expression of Specific Transporters in the Small Intestine." in: PLoS ONE, Vol. 11, Issue 9, pp. e0162475, (2016) (PubMed).

Zhu, Lin, Dai, Zhou, Li, Yuan, Wu, Wu, Wang: "L-Glutamine deprivation induces autophagy and alters the mTOR and MAPK signaling pathways in porcine intestinal epithelial cells." in: Amino acids, Vol. 47, Issue 10, pp. 2185-97, (2015) (PubMed).

Bungard, McGivan: "Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers." in: Archives of biochemistry and biophysics, Vol. 443, Issue 1-2, pp. 53-9, (2005) (PubMed).

Details zu SLC1A5

Target: SLC1A5 (Solute Carrier Family 1 Member 5 (SLC1A5))

Andere Bezeichnung: SLC1A5 (SLC1A5 Produkte)

Synonyme: aaat antikoerper, asct2 antikoerper, atbo antikoerper, m7v1 antikoerper, m7vs1 antikoerper, r16 antikoerper, rdrc antikoerper, AAAT antikoerper, ASCT2 antikoerper, ATBO antikoerper, M7V1 antikoerper, M7VS1 antikoerper, R16 antikoerper, RDRC antikoerper, Slc1a7 antikoerper, Asct2 antikoerper, H4-ASCT2 antikoerper, solute carrier family 1 (neutral amino acid transporter), member 5 antikoerper, solute carrier family 1 member 5 S homeolog antikoerper, solute carrier family 1 member 5 antikoerper, slc1a5 antikoerper, slc1a5.S antikoerper, SLC1A5 antikoerper, Slc1a5 antikoerper

Hintergrund: SLC1A5 has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. It acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses.
Alias Symbols: AAAT, ASCT2, ATBO, FLJ31068, M7V1, M7VS1, R16, RDRC
Protein Interaction Partner: UBC, FUS, LGR4, ADRB2, ALB, PAXIP1, ECT2, MCU, MRPS35, CYB5R3, CAND1, CUL3, USP50, USP19, TBC1D17, ERVW-1, NEK6, MPDU1, LGALS9,
Protein Size: 541

Molekulargewicht: 56 kDa

Gen-ID: 6510

NCBI Accession: NM_005628, NP_005619

UniProt: Q71UA6

Pathways: Dicarboxylic Acid Transport, Warburg Effekt