NAMPT Antikörper (C-Term)

Produktnummer ABIN2775322

Produktdetails anti-NAMPT Antikörper

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio), Hund, Meerschweinchen, Rind (Kuh), Pferd, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAMPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: VTLEEGKGDL EEYGQDLLHT VFKNGKVTKS YSFDEIRKNA QLNIELEAAH

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PBEF1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PBEF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 491 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-NAMPT Antikörper (ABIN2775322)

Xia, Weisenburger, Koch, Burkart, Reifenberg, Förstermann, Li: "Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight." in: British journal of pharmacology, Vol. 174, Issue 20, pp. 3443-3453, (2017) (PubMed).

Details zu NAMPT

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Andere Bezeichnung: PBEF1 (NAMPT Produkte)

Hintergrund: PBEF1 catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It also activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
Alias Symbols: 1110035O14Rik, DKFZP666B131, MGC117256, NAMPT, PBEF, VF, PBEF1, VISFATIN
Protein Interaction Partner: UBC, NEDD8, NDRG1, CTSA, PEPD, MVD, GSR, ASS1, ANXA6, CD81, AKT2, ADORA2A, IFITM3, ND1, GGT1, FTL, CUL5, DDA1, GBAS, FANCA,
Protein Size: 491

Molekulargewicht: 54 kDa

Gen-ID: 10135

NCBI Accession: NM_005746, NP_005737

UniProt: P43490