GAPVD1 Antikörper (N-Term)

Produktnummer ABIN2775423

Produktdetails anti-GAPVD1 Antikörper

Target: GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GAPVD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against GAPVD1. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GAPVD1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1487 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GAPVD1

Target: GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))

Andere Bezeichnung: GAPVD1 (GAPVD1 Produkte)

Synonyme: zgc:92666 antikoerper, GAPEX5 antikoerper, RAP6 antikoerper, 2010005B09Rik antikoerper, 4432404J10Rik antikoerper, AW108497 antikoerper, Gapex-5 antikoerper, RME-6 antikoerper, mKIAA1521 antikoerper, RGD1307479 antikoerper, GTPase activating protein and VPS9 domains 1 antikoerper, GTPase activating protein and VPS9 domains 1 S homeolog antikoerper, LOAG_00609 antikoerper, GAPVD1 antikoerper, gapvd1 antikoerper, gapvd1.S antikoerper, Gapvd1 antikoerper

Hintergrund: GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
Alias Symbols: DKFZP434C212, KIAA1521, MGC138847, MGC138848, RAP6, GAPEX5
Protein Interaction Partner: UBC, FOXK1, LRRC47, SF3A1, HNRNPR, IQGAP1, CCDC6, NR3C1, YWHAB, COPS2, SIRT7, ELAVL1, VAV2, RAD21, Csnk1e, CBL,
Protein Size: 1487

Molekulargewicht: 166 kDa

Gen-ID: 26130

NCBI Accession: NM_015635, NP_056450