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ube3a Antikörper (Middle Region)

ube3a Reaktivität: Human, Maus, Ratte, Kaninchen, Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Rind (Kuh) WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2775648
  • Target Alle ube3a Antikörper anzeigen
    ube3a (Ubiquitin Protein Ligase E3A (ube3a))
    Bindungsspezifität
    • 15
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 51
    • 11
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Kaninchen, Hund, Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Rind (Kuh)
    Wirt
    • 46
    • 5
    Kaninchen
    Klonalität
    • 46
    • 5
    Polyklonal
    Konjugat
    • 28
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ube3a Antikörper ist unkonjugiert
    Applikation
    • 27
    • 17
    • 16
    • 13
    • 13
    • 9
    • 9
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Sequenz
    AKNGPDTERL PTSHTCFNVL LLPEYSSKEK LKERLLKAIT YAKGFGML
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Produktmerkmale
    This is a rabbit polyclonal antibody against UBE3A. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human UBE3A
    Top Product
    Discover our top product ube3a Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 875 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    ube3a (Ubiquitin Protein Ligase E3A (ube3a))
    Andere Bezeichnung
    UBE3A (ube3a Produkte)
    Synonyme
    ANCR antikoerper, AS antikoerper, E6-AP antikoerper, EPVE6AP antikoerper, HPVE6A antikoerper, DDBDRAFT_0188760 antikoerper, DDBDRAFT_0302447 antikoerper, DDB_0188760 antikoerper, DDB_0302447 antikoerper, ube3a antikoerper, im:7140733 antikoerper, zgc:92173 antikoerper, 4732496B02 antikoerper, 5830462N02Rik antikoerper, A130086L21Rik antikoerper, Hpve6a antikoerper, mKIAA4216 antikoerper, As antikoerper, CG6190 antikoerper, Dmel\\CG6190 antikoerper, Dube3a antikoerper, UBE3A antikoerper, dUBE3A antikoerper, das antikoerper, dube3A antikoerper, dube3a antikoerper, MGC69536 antikoerper, UME3A antikoerper, ubiquitin protein ligase E3A antikoerper, ubiquitin-protein ligase E3A antikoerper, Ubiquitin protein ligase E3A antikoerper, ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) S homeolog antikoerper, ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) antikoerper, UBE3A antikoerper, ube3a antikoerper, LOC100194730 antikoerper, Ube3a antikoerper, ube3a.S antikoerper, Eint_040430 antikoerper
    Hintergrund
    UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
    Alias Symbols: ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
    Protein Interaction Partner: KLHL38, UBE2D1, UBB, TP53, TAT, AFG3L1P, ATG9A, ASAP3, AHSP, UBE3A, UBC, MEOX2, MAGEA8, JADE1, YOD1, UBE2L3, UBE2D3, PSMD14, SHFM1, ARNTL, LPP, HSF1, DR1, BTF3L4, LRSAM1, P3H1, NPLOC4, IPO11, DBNL, LSM1, ARPC1B, METTL1, SACS, ARC, RAD23A, PTPN3, CEBPA, SC
    Protein Size: 875
    Molekulargewicht
    101 kDa
    Gen-ID
    7337
    NCBI Accession
    NM_000462, NP_000453
    UniProt
    Q05086
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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