RFFL Antikörper (Middle Region)

Produktnummer ABIN2775666

Produktdetails anti-RFFL Antikörper

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Pferd, Hund, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFFL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KDQKGLQHLV SGAEDQNGGA VPSGLEENLC KICMDSPIDC VLLECGHMVT

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RFFL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RFFL

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 363 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-RFFL Antikörper (ABIN2775666)

Hanuszkiewicz, Pittock, Humphries, Moll, Rosales, Molinaro, Moynagh, Lajoie, Valvano: "Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19231-44, (2014) (PubMed).

Details zu RFFL

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Andere Bezeichnung: RFFL (RFFL Produkte)

Hintergrund: RFFL has E3 ubiquitin protein ligase activity.RFFL regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity.RFFL may bind phosphatidylinositol phosphates.
Alias Symbols: RNF189, RNF34L, CARP2, FRING, CARP-2, RIFIFYLIN
Protein Interaction Partner: RIPK1, UBE2D1, UBC, UBE2D2, RFFL, ATXN3L, OTUB2, USP28, OTUB1, UCHL5, ESPL1, USP5, STAM, USP7, UBE2D3, ATXN3, TP53, MDM2, UBE2G2,
Protein Size: 363

Molekulargewicht: 40 kDa

Gen-ID: 117584

NCBI Accession: NM_001017368, NP_001017368

UniProt: Q8WZ73