UBE2D1 Antikörper (Middle Region)

Produktnummer ABIN2775671

Der Kaninchen Polyklonal Anti-UBE2D1-Antikörper wurde für WB validiert. Er ist geeignet, UBE2D1 in Proben von Human, Maus, Ratte, Hund, Rind (Kuh), Ziege, Pferd, Schwein, Meerschweinchen, Kaninchen und Zebrafisch (Danio rerio) zu detektieren.

Kurzübersicht für UBE2D1 Antikörper (Middle Region) (ABIN2775671)

Target: UBE2D1 (Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Ziege, Pferd, Schwein, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-UBE2D1 Antikörper

Bindungsspezifität: Middle Region

Sequenz: SQWSPALTVS KVLLSICSLL CDPNPDDPLV PDIAQIYKSD KEKYNRHARE

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against UBE2D1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UBE2D1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 147 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu UBE2D1

Target: UBE2D1 (Ubiquitin-Conjugating Enzyme E2D 1 (UBE2D1))

Andere Bezeichnung: UBE2D1

Hintergrund: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D1 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.
Alias Symbols: E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A
Protein Interaction Partner: RBX1, STUB1, RNF7, RNF14, MID1, MDM2, EP300, CREBBP, ANAPC11, DTL, RNF115, MKRN2, NEDD4L, FAF2, TRIM32, MID2, RNF111, RNF5, RSP5, GPB1, NHLRC1, RFFL, UHRF2, DTX2, ZNRF1, TRIM63, RNF146, FBXO31, RNF26, TRIM39, RNF126, FBXW7, NEDD4, CUL1, CUL3, MKRN3, UBE3A
Protein Size: 147

Molekulargewicht: 16 kDa

Gen-ID: 7321

NCBI Accession: NM_001204880, NP_003329

UniProt: P51668

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades