CDC23 Antikörper (C-Term)

Produktnummer ABIN2775691

Produktdetails anti-CDC23 Antikörper

Target: CDC23 (Cell Division Cycle 23 (CDC23))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Pferd, Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC23 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DTREEGKALL RQILQLRNQG ETPTTEVPAP FFLPASLSAN NTPTRRVSPL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against CDC23. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CDC23

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 591 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu CDC23

Target: CDC23 (Cell Division Cycle 23 (CDC23))

Andere Bezeichnung: CDC23 (CDC23 Produkte)

Hintergrund: CDC23 shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
Alias Symbols: APC8, CUT23, ANAPC8
Protein Interaction Partner: CCDC36, DLX6-AS1, SPERT, KCTD6, FAM9B, CCDC24, SSX2IP, PNMA5, CRACR2A, LZTS2, ATRIP, INCA1, CEP44, SLC52A2, EIF5A2, BCAS3, CYB5R2, HEMK1, RSL24D1, RBM15B, ANAPC2, UBE2S, INPP5J, GORASP2, ANAPC13, RAD54B, RBPMS, OPTN, CDC23, APOL1, COIL, UBC, SOX5, SIAH1,
Protein Size: 591

Molekulargewicht: 65 kDa

Gen-ID: 8697

NCBI Accession: NM_004661, NP_004652

UniProt: Q9UJX2

Pathways: Protein targeting to Nucleus