CBX1 Antikörper (N-Term)

Produktnummer ABIN2775787

Produktdetails anti-CBX1 Antikörper

Target: CBX1 (Chromobox Homolog 1 (CBX1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Pferd, Kaninchen, Saccharomyces cerevisiae, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MGKKQNKKKV EEVLEEEEEE YVVEKVLDRR VVKGKVEYLL KWKGFSDEDN

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against CBX1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CBX1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 185 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CBX1 Antikörper (ABIN2775787)

Ayoub, Jeyasekharan, Bernal, Venkitaraman: "HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response." in: Nature, Vol. 453, Issue 7195, pp. 682-6, (2008) (PubMed).

Details zu CBX1

Target: CBX1 (Chromobox Homolog 1 (CBX1))

Andere Bezeichnung: CBX1 (CBX1 Produkte)

Synonyme: CBX antikoerper, HP1-BETA antikoerper, HP1Hs-beta antikoerper, HP1Hsbeta antikoerper, M31 antikoerper, MOD1 antikoerper, p25beta antikoerper, Cbx antikoerper, Cbx-rs2 antikoerper, E430007M08Rik antikoerper, HP1B antikoerper, Hp1beta antikoerper, cbx1 antikoerper, wu:fe14b09 antikoerper, zgc:55739 antikoerper, zgc:86924 antikoerper, chromobox 1 antikoerper, chromobox homolog 1a (HP1 beta homolog Drosophila) antikoerper, chromobox 1 S homeolog antikoerper, chromobox homolog 1b (HP1 beta homolog Drosophila) antikoerper, CBX1 antikoerper, Cbx1 antikoerper, cbx1a antikoerper, cbx1.S antikoerper, cbx1b antikoerper

Hintergrund: CBX1 is the component of heterochromatin. CBX1 recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. CBX1 interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the in
Alias Symbols: CBX, HP1-BETA, HP1Hs-beta, M31, MOD1, p25beta, HP1Hsbeta
Protein Interaction Partner: PRDM6, SUMO1, UBC, RNF2, PARK2, NR2F6, VHL, EHMT2, ABI3BP, VTN, TRIM39, CBX5, HIST1H3B, KLF11, HIST3H3, PCNA, MECP2, ADNP, POGZ, ADNP2, CBX3, TRIM28, CHAF1A, HIST1H4F, XRCC6, CHD4, H2AFB1, NSL1, SUMO2, HIST1H3A, Mad2l2, Cbx1, DNMT3B, ZNF382, H3F3A, SUV420
Protein Size: 185

Molekulargewicht: 21 kDa

Gen-ID: 10951

NCBI Accession: NM_006807, NP_006798

UniProt: P83916