LIN28A Antikörper (N-Term)

Produktnummer ABIN404945

Produktdetails anti-LIN28A Antikörper

Target: LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Hund, Schaf, Kaninchen, Saccharomyces cerevisiae, Ziege, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIN28A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: GSVSNQQFAG GCAKAAEEAP EEAPEDAARA ADEPQLLHGA GICKWFNVRM

Homologie: Cow: 100%, Dog: 100%, Goat: 91%, Guinea Pig: 86%, Human: 100%, Mouse: 90%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Yeast: 77%

Produktmerkmale: This is a rabbit polyclonal antibody against LIN28. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LIN28

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 209 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu LIN28A

Target: LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Andere Bezeichnung: LIN28 (LIN28A Produkte)

Hintergrund: LIN28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. The association of LIN28 with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. IT binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. LIN28 is Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression.
Alias Symbols: CSDD1, FLJ12457, LIN-28, LIN28A, ZCCHC1, LIN28, lin-28A
Protein Interaction Partner: HNRNPUL2, HNRNPA3, DHX36, SREK1, TRIM71, LARP4, TGS1, DHX57, GADD45GIP1, LTV1, NOA1, DDX50, KRI1, NOL6, METTL17, NOC3L, ZC3HAV1, PPAN, CCBL2, MEPCE, TSR1, NHP2, NOP10, STRBP, BRIX1, RBM28, PHAX, SRRT, LARP7, DDX41, HP1BP3, NOB1, PRPF19, ZBTB11, SND1, AATF
Protein Size: 209

Molekulargewicht: 23 kDa

Gen-ID: 79727

NCBI Accession: NM_024674, NP_078950

UniProt: Q9H9Z2

Pathways: Stem Cell Maintenance