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MBD4 Antikörper (Middle Region)

MBD4 Reaktivität: Human, Meerschweinchen WB, ChIP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2776028
  • Target Alle MBD4 Antikörper anzeigen
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Bindungsspezifität
    • 9
    • 9
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 32
    • 5
    • 3
    Human, Meerschweinchen
    Wirt
    • 31
    • 1
    • 1
    Kaninchen
    Klonalität
    • 32
    • 1
    Polyklonal
    Konjugat
    • 16
    • 4
    • 4
    • 3
    • 3
    • 3
    Dieser MBD4 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 24
    • 10
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
    Sequenz
    CSEQKTSGII NKFCSAKDSE HNEKYEDTFL ESEEIGTKVE VVERKEHLHT
    Homologie
    Guinea Pig: 83%, Human: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against MBD4. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human MBD4
    Top Product
    Discover our top product MBD4 Primärantikörper
  • Applikationshinweise
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 580 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
    Andere Bezeichnung
    MBD4 (MBD4 Produkte)
    Synonyme
    MED1 antikoerper, Med1 antikoerper, methyl-CpG binding domain 4, DNA glycosylase antikoerper, methyl-CpG binding domain protein 4 antikoerper, methyl-CpG binding domain 4 DNA glycosylase antikoerper, MBD4 antikoerper, Mbd4 antikoerper
    Hintergrund
    MBD4 is involved with DNA methylation. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD3 comprise a family of nuclear proteins related by??he presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MED1
    Protein Interaction Partner: KDM1A, SUV39H1, HTT, FAS, SUMO2, UBC, CDCA2, Trim27, FADD, MLH1, CSNK2B, DNMT3B, SIN3A, HDAC1,
    Protein Size: 580
    Molekulargewicht
    66 kDa
    Gen-ID
    8930
    NCBI Accession
    NM_003925, NP_003916
    UniProt
    O95243
    Pathways
    DNA Reparatur
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