DMP1 Antikörper (Middle Region)

Produktnummer ABIN2776044

Produktdetails anti-DMP1 Antikörper

Target: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Kaninchen, Meerschweinchen, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: TFPDEIHHPK MTVEPSFNDA HVSKFSDQNS TELMNSVMVR TEEEISDTDL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against DMTF1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DMTF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 760 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DMP1

Target: DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))

Andere Bezeichnung: DMTF1 (DMTF1 Produkte)

Synonyme: DMP1 antikoerper, DMTF antikoerper, hDMP1 antikoerper, Dimp antikoerper, Dmp1 antikoerper, DMTF1 antikoerper, zgc:92448 antikoerper, cyclin D binding myb like transcription factor 1 antikoerper, cyclin D binding myb-like transcription factor 1 antikoerper, DMTF1 antikoerper, Dmtf1 antikoerper, dmtf1 antikoerper

Hintergrund: DMTF1 is a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. DMTF1 is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of DMTF1 is regulated by binding of D-cyclins. The gene encoding DMTF1 is hemizygously deleted in approximately 40 % of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer.
Alias Symbols: DMP1, DMTF, FLJ41265, hDMP1
Protein Interaction Partner: SRA1, TP53, ATF7IP, CCND1, CCND3, CCND2,
Protein Size: 760

Molekulargewicht: 84 kDa

Gen-ID: 9988

NCBI Accession: NM_021145, NP_066968

UniProt: Q9Y222