SCN5A Antikörper (N-Term)
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- Target Alle SCN5A Antikörper anzeigen
- SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio), Kaninchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SCN5A Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequenz
- SEADFADDEN STAGESESHH TSLLVPWPLR RTSAQGQPSP GTSAPGHALH
- Homologie
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%
- Produktmerkmale
- This is a rabbit polyclonal antibody against SCN5A. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human SCN5A
- Top Product
- Discover our top product SCN5A Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 2015 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy." in: Clinical and experimental pharmacology & physiology, Vol. 41, Issue 1, pp. 89-97, (2013) (PubMed).
: "
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Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy." in: Clinical and experimental pharmacology & physiology, Vol. 41, Issue 1, pp. 89-97, (2013) (PubMed).
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- Target
- SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
- Andere Bezeichnung
- SCN5A (SCN5A Produkte)
- Synonyme
- Nav1.5 antikoerper, Nav1.5c antikoerper, SkM1 antikoerper, SkM2 antikoerper, mH1 antikoerper, CDCD2 antikoerper, CMD1E antikoerper, CMPD2 antikoerper, HB1 antikoerper, HB2 antikoerper, HBBD antikoerper, HH1 antikoerper, ICCD antikoerper, IVF antikoerper, LQT3 antikoerper, PFHB1 antikoerper, SSS1 antikoerper, VF1 antikoerper, SCAL antikoerper, sodium voltage-gated channel alpha subunit 5 antikoerper, sodium channel, voltage-gated, type V, alpha antikoerper, SCN5A antikoerper, Scn5a antikoerper
- Hintergrund
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SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.
Alias Symbols: CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1
Protein Interaction Partner: CALM1, CAV3, ALB, Nedd4, WWP2, UBC, SNTG2, NEDD4L, DLG2, INADL, DLG4, RGS3, SNTA1, DLG1, RGS2, SCN5A, SNTB2, SNTB1, DLG3, CBL,
Protein Size: 2015 - Molekulargewicht
- 227 kDa
- Gen-ID
- 6331
- NCBI Accession
- NM_000335, NP_000326
- UniProt
- Q14524
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