KCNN3 Antikörper (C-Term)

Produktnummer ABIN2776146

Produktdetails anti-KCNN3 Antikörper

Target: KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: ITELNDRSED LEKQIGSLES KLEHLTASFN SLPLLIADTL RQQQQQLLSA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KCNN3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human KCNN3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 736 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KCNN3

Target: KCNN3 (Small Conductance Calcium-Activated Potassium Channel Protein 3 (KCNN3))

Andere Bezeichnung: KCNN3 (KCNN3 Produkte)

Synonyme: KCa2.3 antikoerper, SK3 antikoerper, SKCA3 antikoerper, hSK3 antikoerper, potassium calcium-activated channel subfamily N member 3 antikoerper, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 antikoerper, Kcnn3 antikoerper, KCNN3 antikoerper

Hintergrund: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.
Alias Symbols: SK3, hSK3, SKCA3, KCa2.3
Protein Interaction Partner: UBC, RAB5A, DNM2, CAV1, APP, CALM1,
Protein Size: 736

Molekulargewicht: 81 kDa

Gen-ID: 3782

NCBI Accession: NM_002249, NP_002240

UniProt: Q9UGI6